产品名称

英文名称：INCB024360 analogue

同义词

914471-09-3、INCB024360、IDO5L、4-Amino-N-(3-chloro-4-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide、INCB14943、4-Amino-N'-(3-chloro-4-fluorophenyl)-N-hydroxy-1,2,5-oxadiazole-3-carboximidamide、CHEMBL584991、4-Amino-N-(3-chloro-4-fluorophenyl)-N'-

产品性质

CAS编号：914471-09-3

分子式：C9H7ClFN5O2

分子量：271.64

PubChem编号：135424953

英文别名：914471-09-3|INCB024360|IDO5L|4-Amino-N-(3-chloro-4-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide|INCB14943|4-Amino-N'-(3-chloro-4-fluorophenyl)-N-hydroxy-1,2,5-oxadiazole-3-carboximidamide|CHEMBL584991|4-Amino-N-(3-chloro-4-fluorophenyl)-N'-

规格或纯度：≥98%

英文名称：INCB024360 analogue

生化机理：高效吲哚胺2,3-二加氧酶（IDO）抑制剂（酶活性和HeLa细胞分析的IC50值分别为19和67 nM）。降低血浆犬尿氨酸水平并降低体内肿瘤生长。细胞膜可渗透。

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：5mg、25mg、100mg卖完停产，不再备货

产品介绍：IDO5L是高活性IDO1抑制剂，IC50为67 nM。A competitive indoleamine 2,3-dioxygenase inhibitorINCB024360 analogue is a potent, competitive IDO1 (indoleamine-(2,3)-dioxygenase) inhibitor with IC50 of 67 nMA competitive indoleamine 2,3-dioxygenase inhibitor

IUPAC Name：4-amino-N'-(3-chloro-4-fluorophenyl)-N-hydroxy-1,2,5-oxadiazole-3-carboximidamide

INCHI：InChI=1S/C9H7ClFN5O2/c10-5-3-4(1-2-6(5)11)13-9(14-17)7-8(12)16-18-15-7/h1-3,17H,(H2,12,16)(H,13,14)

InChi Key：HGXSLPIXNPASGZ-UHFFFAOYSA-N

Canonical SMILES：C1=CC(=C(C=C1N=C(C2=NON=C2N)NO)Cl)F

Isomeric SMILES：C1=CC(=C(C=C1N=C(C2=NON=C2N)NO)Cl)F

PubChem CID：135424953

溶解性：溶于DMSO, 最高浓度 (mg/mL) 27.16, 最高浓度(mM) 100；溶于ethanol, 最高浓度 (mg/mL) 27.16, 最高浓度(mM) 100

密度：1.8

折光率：1.72

沸点：~318.6 °C at 760 mmHg

熔点：154.74°C

产品包装