产品分类

应用/药物靶标/激酶/CMGC：包含CDK，MAPK，GSK3，CLK家族

产品名称

英文名称：JNK-IN-7

同义词

JNK inhibitor;3-((4-(dimethylamino)-1-oxo-2-buten-1-yl)amino)-n-(4-((4-(3-pyridinyl)-2-pyrimidinyl)amino)phenyl)benzamide、JNK inhibitor

产品性质

CAS编号：1408064-71-0

分子式：C28H27N7O2

分子量：493.56

PubChem编号：57340685

规格或纯度：≥98%

英文名称：JNK-IN-7

生化机理：Covalent modification of IRAK1 by JNK-IN-7 is a possibility and subsequent biochemical kinase assay revealed anIC50 of ~10 nM against IRAK1. JNK-IN-7 exhibited binding inhibition of 95% or more to approximately 14 kinases at the concentration of 1.0 μM. JNK-IN-7 was next tested for its ability to inhibit the enzymatic activity of a panel of 121 kinases at a concentration of 1.0 μM

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：卖完停产，不再备货

产品介绍：JNK-IN-7是 JNK1，2，3抑制剂，IC50分别为1.54，1.99，0.75 nM，还能结合IRAK1，PIK3C3，PIP5K3和PIP4K2C。JNK-IN-7 is a relatively selective JNKs inhibitor(IC50= 1.54/1.99/0.75 for JNK1/2/3); also bound to IRAK1, PIK3C3, PIP5K3 and PIP4K2C.

IUPAC Name：3-[[(E)-4-(dimethylamino)but-2-enoyl]amino]-N-[4-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide

INCHI：InChI=1S/C28H27N7O2/c1-35(2)17-5-9-26(36)31-24-8-3-6-20(18-24)27(37)32-22-10-12-23(13-11-22)33-28-30-16-14-25(34-28)21-7-4-15-29-19-21/h3-16,18-19H,17H2,1-2H3,(H,31,36)(H,32,37)(H,30,33,34)/b9-5+

InChi Key：RADRIIWGHYFWPP-WEVVVXLNSA-N

Canonical SMILES：CN(C)CC=CC(=O)NC1=CC=CC(=C1)C(=O)NC2=CC=C(C=C2)NC3=NC=CC(=N3)C4=CN=CC=C4

PubChem CID：57340685

溶解性：25°C DMSO

产品包装