产品名称

英文名称：VcMMAE

同义词

VcMMAE、646502-53-6、MC-vc-PAB-MMAE、MC-Val-Cit-PAB-MMAE、026S2O80A8、Vc-MMAE、MFCD25372036、UNII-026S2O80A8、VEDOTIN PARENT、SCHEMBL12813464、AMY9237、EX-A1506、SGD-1006、WAB50253、s6661、AKOS037643764、CS-1242、AC-32509、AS-35255、HY-15575、A14362、Q27231498、Maleimidocaproy

产品性质

CAS编号：646502-53-6

分子式：C68H105N11O15

分子量：1316.63

PubChem编号：46944733

英文别名：VcMMAE|646502-53-6|MC-vc-PAB-MMAE|MC-Val-Cit-PAB-MMAE|026S2O80A8|Vc-MMAE|MFCD25372036|UNII-026S2O80A8|VEDOTIN PARENT|SCHEMBL12813464|AMY9237|EX-A1506|SGD-1006|WAB50253|s6661|AKOS037643764|CS-1242|AC-32509|AS-35255|HY-15575|A14362|Q27231498|Maleimidocaproy

规格或纯度：98%

英文名称：VcMMAE

生化机理：VcMMAE is an antibody-drμg conjμgate (ADC) with potent antitumor activity by using the anti-mitotic agent, monomethyl auristatin E (MMAE), linked via the lysosomally cleavable dipeptide, valine-citrulline (vc). Antibody-drμg conjμgates (ADCs) are designed to combine the exquisite specificity of antibodies to target tumor antigens with the cytotoxic potency of chemotherapeutic drμgs. In vivo studies demonstrated that the peptide-linked conjμgates induced regressions and cures of established tumor xenografts with therapeutic indices as high as 60-fold. These conjμgates illustrate the importance of linker technology, drμg potency and conjμgation methodology in developing safe and efficacious mAb-drμg conjμgates for cancer therapy.

储存温度：-20°C储存,充氩

运输条件：超低温冰袋运输

产品介绍：产品介绍VcMMAE (mc-vc-PAB-MMAE)，一种具有缬氨酸-瓜氨酸(Vc)接头的MMAE衍生物，是具有抗肿瘤活性的antibody-drug conjugate (ADC)。MMAE是一种合成的抗肿瘤药，在体外可以有效地从VcMMAE释放出来并发挥细胞毒活性。

IUPAC Name：[4-[[(2S)-5-(carbamoylamino)-2-[[(2S)-2-[6-(2,5-dioxopyrrol-1-yl)hexanoylamino]-3-methylbutanoyl]amino]pentanoyl]amino]phenyl]methyl N-[(2S)-1-[[(2S)-1-[[(3R,4S,5S)-1-[(2S)-2-[(1R,2R)-3-[[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]amino]-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl]-methylamino]-3-methyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]-N-methylcarbamate

INCHI：InChI=1S/C68H105N11O15/c1-15-43(8)59(51(92-13)38-55(83)78-37-23-27-50(78)61(93-14)44(9)62(85)71-45(10)60(84)47-24-18-16-19-25-47)76(11)66(89)57(41(4)5)75-65(88)58(42(6)7)77(12)68(91)94-39-46-29-31-48(32-30-46)72-63(86)49(26-22-35-70-67(69)90)73-64(87)56(40(2)3)74-52(80)28-20-17-21-36-79-53(81)33-34-54(79)82/h16,18-19,24-25,29-34,40-45,49-51,56-61,84H,15,17,20-23,26-28,35-39H2,1-14H3,(H,71,85)(H,72,86)(H,73,87)(H,74,80)(H,75,88)(H3,69,70,90)/t43-,44+,45+,49-,50-,51+,56-,57-,58-,59-,60+,61+/m0/s1

InChi Key：NLMBVBUNULOTNS-HOKPPMCLSA-N

Canonical SMILES：CCC(C)C(C(CC(=O)N1CCCC1C(C(C)C(=O)NC(C)C(C2=CC=CC=C2)O)OC)OC)N(C)C(=O)C(C(C)C)NC(=O)C(C(C)C)N(C)C(=O)OCC3=CC=C(C=C3)NC(=O)C(CCCNC(=O)N)NC(=O)C(C(C)C)NC(=O)CCCCCN4C(=O)C=CC4=O

Isomeric SMILES：CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@@H]([C@@H](C)C(=O)N[C@H](C)[C@H](C2=CC=CC=C2)O)OC)OC)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)N(C)C(=O)OCC3=CC=C(C=C3)NC(=O)[C@H](CCCNC(=O)N)NC(=O)[C@H](C(C)C)NC(=O)CCCCCN4C(=O)C=CC4=O

PubChem CID：46944733

溶解性：Insoluble in water, soluble in ethanol

象形图：

信号词：Danger

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH300 Fatal if swallowedH310 Fatal in contact with skinH330 Fatal if inhaledH300+H310+H330 Fatal if swallowed, in contact with skin or if inhaled

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P260,P284,P271,P270,P304+P340,P403+P233,P362+P364,P330,P262,P320,P361+P364,P264+P265,P301+P316,P337+P317,P332+P317,P316,P319

产品包装