产品名称

英文名称：SRPIN340

同义词

SRPIN340、218156-96-8、N-(2-(Piperidin-1-yl)-5-(trifluoromethyl)phenyl)isonicotinamide、SRPIN 340、SRPK inhibitor、N-[2-(1-Piperidinyl)-5-(trifluoromethyl)phenyl]-4-pyridinecarboxamide、CHEMBL4064277、N-[2-(Piperidin-1-yl)-5-(trifluoromethyl)phenyl]pyridine-4-ca

产品性质

CAS编号：218156-96-8

分子式：C18H18F3N3O

分子量：349.35

PubChem编号：2797577

英文别名：SRPIN340|218156-96-8|N-(2-(Piperidin-1-yl)-5-(trifluoromethyl)phenyl)isonicotinamide|SRPIN 340|SRPK inhibitor|N-[2-(1-Piperidinyl)-5-(trifluoromethyl)phenyl]-4-pyridinecarboxamide|CHEMBL4064277|N-[2-(Piperidin-1-yl)-5-(trifluoromethyl)phenyl]pyridine-4-ca

规格或纯度：≥98%

英文名称：SRPIN340

生化机理：SRPIN340 is a cell-permeable, specific and potent inhibitor of Serine-Arginine-Rich Protein Kinase (SRPK) that down-regulates SRp75 and inhibits expression of Sindbis, hepatitis C virus (HCV), HIV, and cytomegalovirus viruses. SRPIN340 appears to be most effective for inhibiting acutely replicating viruses. SRPIN340 suppresses Vegf expression and attenuated choroidal neovascularization (CNV) formation in mice model. SRPIN340 is an isonicotinamide compound. It protects cardiomyocytes against hydrogen peroxide (H2O2) induced oxidative damage by serine-arginine protein kinase 1/2 (SRPK1/2) inhibition-mediated protein kinase B (AKT) activation.

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：SRPIN340是选择性SRPK抑制剂，作用于SRPK1, Ki为0.89 μM ，对其他140多种激酶没有显著的抑制活性。An SRPK1 inhibitor.SRPIN340 has been used as a serine-arginine protein kinase (SRPK) inhibitor to identify if SRPK can phosphorylate the E3 ubiquitin ligase RNF12 ser/arg (SR)-motifs in vivo.

IUPAC Name：N-[2-piperidin-1-yl-5-(trifluoromethyl)phenyl]pyridine-4-carboxamide

INCHI：InChI=1S/C18H18F3N3O/c19-18(20,21)14-4-5-16(24-10-2-1-3-11-24)15(12-14)23-17(25)13-6-8-22-9-7-13/h4-9,12H,1-3,10-11H2,(H,23,25)

InChi Key：DWFGGOFPIISJIT-UHFFFAOYSA-N

Canonical SMILES：C1CCN(CC1)C2=C(C=C(C=C2)C(F)(F)F)NC(=O)C3=CC=NC=C3

Isomeric SMILES：C1CCN(CC1)C2=C(C=C(C=C2)C(F)(F)F)NC(=O)C3=CC=NC=C3

WGK Germany：3

PubChem CID：2797577

溶解性：溶于DMSO, 最高浓度 (mg/mL) 34.94, 最高浓度(mM) 100；溶于1eq. HCl, 最高浓度 (mg/mL) 17.47, 最高浓度(mM) 50

象形图：

信号词：Warning

危险声明：H302 Harmful if swallowed

预防措施声明：P501,P264,P270,P330,P301+P317

产品包装