产品名称

英文名称：Erlotinib HCl (OSI-744)

同义词

Erlotinib hydrochloride、183319-69-9、erlotinib HCl、Tarceva、N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine hydrochloride、OSI-774、OSI 774、Erlotinib (Hydrochloride)、CP-358774、UNII-DA87705X9K、CP 358774、Erlotinib 13C6 HCl、DA87705X9K、CP-358、CP-35、盐酸埃罗替尼、774 盐酸盐, CP-358, N-(3-乙炔基苯基)-6,7-双(2-甲氧基乙氧基)喹唑啉-4-胺, OSI-744 盐酸盐、盐酸厄洛替尼、埃罗替尼 盐酸盐

产品性质

CAS编号：183319-69-9

分子式：C22H23N3O4·HCl

分子量：429.9

EC号：620-491-0

PubChem编号：176871

别名：盐酸埃罗替尼|774 盐酸盐, CP-358, N-(3-乙炔基苯基)-6,7-双(2-甲氧基乙氧基)喹唑啉-4-胺, OSI-744 盐酸盐|盐酸厄洛替尼|埃罗替尼 盐酸盐|

英文别名：Erlotinib hydrochloride|183319-69-9|erlotinib HCl|Tarceva|N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine hydrochloride|OSI-774|OSI 774|Erlotinib (Hydrochloride)|CP-358774|UNII-DA87705X9K|CP 358774|Erlotinib 13C6 HCl|DA87705X9K|CP-358|CP-35

规格或纯度：≥99%

英文名称：Erlotinib HCl (OSI-744)

生化机理：Erlotinib hydrochloride is an inhibitor of the receptor tyrosine kinase EGFR (epidermal growth factor receptor). It is used clinically for the treatment of non-small cell lung cancer (NSCLC) and in combination for metastatic pancreatic cancer.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：产品介绍Erlotinib hydrochloride is an antineoplastic drug. It regulates mechanistic target of rapamycin (mTOR) inhibition, epidermal growth factor receptor down-regulation and epidermal interstitial transformation (EMT) suppression. Erlotinib Hydrochloride (CP-358774 Hydrochloride) inhibits purified EGFR kinase with an IC50 of 2 nM.添加用途Erlotinib hydrochloride has been used to activate mitochondrial fragmentation in a human PANC-1 pancreatic cancer cell line.Product DescriptionErlotinib hydrochloride is an antineoplastic drug. It regulates mechanistic target of rapamycin (mTOR) inhibition, epidermal growth factor receptor down-regulation and epidermal interstitial transformation (EMT) suppression. Erlotinib Hydrochloride (CP-358774 Hydrochloride) inhibits purified EGFR kinase with an IC50 of 2 nM.Product ApplicationErlotinib hydrochloride has been used to activate mitochondrial fragmentation in a human PANC-1 pancreatic cancer cell line.

IUPAC Name：N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine;hydrochloride

INCHI：InChI=1S/C22H23N3O4.ClH/c1-4-16-6-5-7-17(12-16)25-22-18-13-20(28-10-8-26-2)21(29-11-9-27-3)14-19(18)23-15-24-22;/h1,5-7,12-15H,8-11H2,2-3H3,(H,23,24,25);1H

InChi Key：GTTBEUCJPZQMDZ-UHFFFAOYSA-N

Canonical SMILES：COCCOC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=CC(=C3)C#C)OCCOC.Cl

Isomeric SMILES：COCCOC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=CC(=C3)C#C)OCCOC.Cl

关联CAS：183319-69-9

PubChem CID：176871

NSC Number：718781

MeSH Entry Terms：11C erlotinib;11C-erlotinib;358,774, CP;358774, CP;CP 358,774;CP 358774;CP-358,774;CP-358774;CP358,774;CP358774;erlotinib;erlotinib HCl;erlotinib hydrochloride;HCl, Erlotinib;Hydrochloride, Erlotinib;N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-

溶解性：Soluble in DMSO (3 mg/ml), methanol (sparingly), water (<1 mg/ml), and ethanol (<1 mg/ml).

敏感性：对湿度敏感

象形图：

信号词：Danger

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH301 Toxic if swallowedH351 Suspected of causing cancerH373 Causes damage to organs through prolonged or repeated exposureH411 Toxic to aquatic life with long lasting effectsH413 May cause long lasting harmful effects to aquatic lifeH302 Harmful if swallowedH317 May cause an allergic skin reactionH332 Harmful if inhaledH372 Causes damage to organs through prolonged or repeated exposureH360 May damage fertility or the unborn childH361 Suspected of damaging fertility or the unborn childH302+H332 Harmful if swallowed or if inhaledH362 May cause harm to breast-fed children

预防措施声明：P261,P305+P351+P338,P273,P280,P302+P352,P321,P405,P501,P264,P260,P271,P270,P304+P340,P403+P233,P272,P333+P313,P362+P364,P391,P330,P263,P203,P264+P265,P301+P316,P301+P317,P318,P317,P337+P317,P332+P317,P319

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