产品名称

英文名称：Flunarizine 2HCl

同义词

Flunarizine dihydrochloride、flunarizine hydrochloride、30484-77-6、Flunarizine 2HCl、Flunarizine HCl、27064-95-5、Flunarizine (dihydrochloride)、KW-3149、1-(Bis(4-fluorophenyl)methyl)-4-cinnamylpiperazine dihydrochloride、Flunarizine (as hydrochloride)、(E)-1-(Bis、盐酸氟桂利嗪、(E)-1-[双(4-氟苯基)甲基]-4-(3-苯基-2-丙烯基)-哌嗪二盐酸盐、1-[双(4-氟苯基)甲基]-4-(3-苯基-2-丙烯基)哌嗪 二盐酸盐

产品性质

CAS编号：30484-77-6

分子式：C26H26F2N2·2HCl

分子量：477.42

Beilstein号：4284243

EC号：250-216-6

MDL号：MFCD00058198

PubChem编号：5282407

别名：盐酸氟桂利嗪|(E)-1-[双(4-氟苯基)甲基]-4-(3-苯基-2-丙烯基)-哌嗪二盐酸盐|1-[双(4-氟苯基)甲基]-4-(3-苯基-2-丙烯基)哌嗪 二盐酸盐

英文别名：Flunarizine dihydrochloride|flunarizine hydrochloride|30484-77-6|Flunarizine 2HCl|Flunarizine HCl|27064-95-5|Flunarizine (dihydrochloride)|KW-3149|1-(Bis(4-fluorophenyl)methyl)-4-cinnamylpiperazine dihydrochloride|Flunarizine (as hydrochloride)|(E)-1-(Bis

规格或纯度：≥99%

英文名称：Flunarizine 2HCl

生化机理：Flunarizine ? 2HCl, a calcium channel protein inhibitor and antagonist, has been shown to inhibit contraction of isolated murine caudal artery preparations. Mechanistic studies sμggest that this compound inhibits prostaglandin-induced and Serotonin ? HCl induced components of the contraction via reduction in the amounts of TXB2 (Thromboxane B2) and ALK-1, and an increase in production of HETE. Experiments on rabbit sino-atrial nodes and isolated guinea-pig papillary muscles have reported that Flunarizine ? 2HCl depressed the slow action potentials of K+-depolarized papillary muscle. Additionally, studies indicate that Flunarizine ? 2HCl selectively suppresses Ca2+ influx throμgh the cell membrane of sino-atrial nodes.Potent dual Na + /Ca 2+ channel blocker (IC 50 values are 0.4 and 2.2 μM for Na + and voltage-gated T-type Ca2+ channels respectively). Shows vasodilatory and neuroprotective effects in vivo. Orally active .

储存温度：2-8°C储存

运输条件：冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Flunarizine 2HCl是一种二氢盐酸盐，抑制钙离子通道，Ki为68 nM。A calcium channel protein inhibitor.Flunarizine 2HCl is a dihydrochloride salt form which is a calcium channel blocker with a Ki of 68 nM.A calcium channel protein inhibitor.

IUPAC Name：1-[bis(4-fluorophenyl)methyl]-4-[(E)-3-phenylprop-2-enyl]piperazine;dihydrochloride

INCHI：InChI=1S/C26H26F2N2.2ClH/c27-24-12-8-22(9-13-24)26(23-10-14-25(28)15-11-23)30-19-17-29(18-20-30)16-4-7-21-5-2-1-3-6-21;;/h1-15,26H,16-20H2;2*1H/b7-4+;;

InChi Key：RXKMOPXNWTYEHI-RDRKJGRWSA-N

Canonical SMILES：C1CN(CCN1CC=CC2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F.Cl.Cl

Isomeric SMILES：C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F.Cl.Cl

WGK Germany：3

RTECS：TK9187000

PubChem CID：5282407

溶解性：Soluble in DMSO (25 mg/mL), ethanol (5 mg/mL warm), methanol, 0.1N HCI, and chloroform/methanol (91) (50 mg/mL). Insoluble in water, and dilute aqueous base..

象形图：

信号词：Warning

危险声明：H302 Harmful if swallowed

预防措施声明：P501,P264,P270,P330,P301+P317

个人防护装备：dust mask type N95 (US), Eyeshields, Gloves

产品包装