产品名称

英文名称：(S)-(+)-Camptothecin

同义词

camptothecin、7689-03-4、Camptothecine、(S)-(+)-Camptothecin、Campathecin、(+)-Camptothecine、d-Camptothecin、(+)-Camptothecin、20(S)-Camptothecine、21,22-Secocamptothecin-21-oic acid lactone、NSC94600、Camptothecine (S,+)、CHEMBL65、(S)-4-ethyl-4-hydroxy-1H-Pyrano[3'

产品性质

CAS编号：7689-03-4

分子式：C20H16N2O4

分子量：348.35

MDL号：MFCD00081076

PubChem编号：24360

英文别名：camptothecin|7689-03-4|Camptothecine|(S)-(+)-Camptothecin|Campathecin|(+)-Camptothecine|d-Camptothecin|(+)-Camptothecin|20(S)-Camptothecine|21,22-Secocamptothecin-21-oic acid lactone|NSC94600|Camptothecine (S,+)|CHEMBL65|(S)-4-ethyl-4-hydroxy-1H-Pyrano[3'

规格或纯度：分析标准品,≥98%

英文名称：(S)-(+)-Camptothecin

生化机理：Camptothecin (CPT), a cytotoxic quinoline alkaloid, is a potent DNA enzyme topoisomerase I (topo I) inhibitor with an IC50 and IC70 of 50 nM and 0.225 μM for breast cancer cell line MDA-MB-231. It has recently been undergoing phase I clinical trials. In 3D fluorescence spectra, Camptothecin presented 3 fluorescence peaks with excitation wavelengths lambdaex of 215, 255 and 365 nm, separately. Camptothecin shows high activity against various tumor cells.

应用：不可逆转地的结合到DNA拓扑异构酶I复合物上，影响细胞周期进程

储存温度：2-8°C储存

运输条件：冰袋运输

产品介绍：微溶于乙醇、氯仿，难溶于水。与酸不能生成稳定的盐，与氢氧化钠溶液加热反应可生成钠盐而溶于水。钠盐水溶液黄色澄明具蓝色荧光

IUPAC Name：(19S)-19-ethyl-19-hydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione

INCHI：InChI=1S/C20H16N2O4/c1-2-20(25)14-8-16-17-12(7-11-5-3-4-6-15(11)21-17)9-22(16)18(23)13(14)10-26-19(20)24/h3-8,25H,2,9-10H2,1H3/t20-/m0/s1

InChi Key：VSJKWCGYPAHWDS-FQEVSTJZSA-N

Canonical SMILES：CCC1(C2=C(COC1=O)C(=O)N3CC4=CC5=CC=CC=C5N=C4C3=C2)O

Isomeric SMILES：CC[C@@]1(C2=C(COC1=O)C(=O)N3CC4=CC5=CC=CC=C5N=C4C3=C2)O

PubChem CID：24360

密度：1.51

比旋光度：+37.0 to +42.0 deg(C=0.4, CHCl3MeOHl=82)

熔点：259-263°C

象形图：

信号词：Danger

危险声明：H301 Toxic if swallowedH340 May cause genetic defects

预防措施声明：P321,P405,P501,P264,P281,P270,P330,P203,P301+P316,P318

Merck Index：1735

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