产品名称

英文名称：Ascomycin

同义词

ascomycin、Immunomycin、104987-12-4、FK520、FR 900520、FK 520、L-683590、AUF4U5NSJK、FK-520、L 683590、CHEMBL8597、CHEBI29582、FR-900520、Ascomycin from Streptomyces hygroscopicus var. ascomyceticus、Changchuanmycin、(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,22R,26aS)-8-、长川霉素、子囊霉素

产品性质

CAS编号：104987-12-4

分子式：C43H69NO12

分子量：792.01

EC号：200-835-2

PubChem编号：5282071

别名：长川霉素|子囊霉素

英文别名：ascomycin|Immunomycin|104987-12-4|FK520|FR 900520|FK 520|L-683590|AUF4U5NSJK|FK-520|L 683590|CHEMBL8597|CHEBI29582|FR-900520|Ascomycin from Streptomyces hygroscopicus var. ascomyceticus|Changchuanmycin|(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,22R,26aS)-8-

规格或纯度：≥97.0%

英文名称：Ascomycin

生化机理：When we used either CD4+CD8+ thymocytes or peripheral T cells activated by phorbol ester and ionomycin, the cell surface induction of CD5 was also partially blocked by CsA, FK-520 and rapamycin . Ascomycinalso had a 3-fold lower immunosuppressive potency in a popliteal lymph node hyperplasia assay, resulting in an equivalent therapeutic index consistent with a common mechanistic dependence on calcineurin inhibition.Calcineurin/PP2B inhibitor (IC 50 = 49 nM). Forms a FK-506 binding protein 12 (FKBP12) - Ascomycin -Calcineurin complex. Immunosuppressant and antifungal activity in vitro and in vivo .

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Ascomycin(Immunomycin, FR-900520, FK520)是tacrolimus (FK506)的类似物，具有很强的免疫抑制剂。A potent immunosuppressive agentAscomycin(Immunomycin, FR-900520, FK520) is an ethyl analog of tacrolimus (FK506) with strong immunosuppressant properties.A potent immunosuppressive agentapplicationAscomycin is a potent immunosuppressive agent that could be used as a potential therapeutic agent for autoimmune diseases. Ascomycin is an inhibitor of PP2. It is an internal standard for LC-MS/MS testing of the immunosuppressants tacrolimus, sirolimus, and everolimus. This Certified Spiking Solution® is suitable for critical quantitative applications in clinical and diagnostic testing such as therapeutic drug monitoring assays to ensure patients remain within the narrow therapeutic range of these immunosuppressants.

PubChem SID：488195248

IUPAC Name：(1R,9S,12S,13R,14S,17R,18E,21S,23S,24R,25S,27R)-17-ethyl-1,14-dihydroxy-12-[(E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.04,9]octacos-18-ene-2,3,10,16-tetrone

INCHI：InChI=1S/C43H69NO12/c1-10-30-18-24(2)17-25(3)19-36(53-8)39-37(54-9)21-27(5)43(51,56-39)40(48)41(49)44-16-12-11-13-31(44)42(50)55-38(28(6)33(46)23-34(30)47)26(4)20-29-14-15-32(45)35(22-29)52-7/h18,20,25,27-33,35-39,45-46,51H,10-17,19,21-23H2,1-9H3/b24-18+,26-20+/t25-,27+,28+,29-,30+,31-,32+,33-,35+,36-,37-,38+,39+,43+/m0/s1

InChi Key：ZDQSOHOQTUFQEM-NURRSENYSA-N

Canonical SMILES：CCC1C=C(CC(CC(C2C(CC(C(O2)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C(CC1=O)O)C)C(=CC4CCC(C(C4)OC)O)C)O)C)OC)OC)C)C

Isomeric SMILES：CC[C@@H]1/C=C(/C[C@@H](C[C@@H]([C@@H]2[C@H](C[C@H]([C@@](O2)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@@H]([C@@H]([C@H](CC1=O)O)C)/C(=C/[C@@H]4CC[C@H]([C@@H](C4)OC)O)/C)O)C)OC)OC)C)\C

WGK Germany：2

RTECS：KD4185000

关联CAS：11011-38-4

PubChem CID：5282071

溶解性：Soluble in DMSO (65 mg/ml), ethanol (50 mg/ml), and water (10-50 μM).

闪点(℉)：230°F

闪点(℃)：>110℃

沸点：868℃

象形图：

信号词：Warning

危险声明：H302 Harmful if swallowedH312 Harmful in contact with skinH332 Harmful if inhaled

预防措施声明：P261,P280,P302+P352,P321,P501,P264,P271,P270,P304+P340,P362+P364,P330,P301+P317,P317

个人防护装备：dust mask type N95 (US)， Eyeshields， Gloves

产品包装