产品名称

英文名称：Nefiracetam

同义词

DM 9384、INF 4668、N-(2,6-Dimethylphenyl)-2-(2-oxo-1-pyrrolidinyl]acetamide、Tox21_113521、AC-32883、Q6039388、DTXSID2020923、NEFIRACETAM [MART.]、T72927、KS-5226、Motiva、Sodium 2-((2,6-dichloro-3-methylphenyl)amino)benzoate、Tox21_113521_1、NSC 759830、BCP21371、SY052、奈非西坦

产品性质

CAS编号：77191-36-7

分子式：C14H18N2O2

分子量：246.3

MDL号：MFCD00209882

PubChem编号：71157

别名：奈非西坦

英文别名：DM 9384|INF 4668|N-(2,6-Dimethylphenyl)-2-(2-oxo-1-pyrrolidinyl]acetamide|Tox21_113521|AC-32883|Q6039388|DTXSID2020923|NEFIRACETAM [MART.]|T72927|KS-5226|Motiva|Sodium 2-((2,6-dichloro-3-methylphenyl)amino)benzoate|Tox21_113521_1|NSC 759830|BCP21371|SY052

规格或纯度：≥98%

英文名称：Nefiracetam

生化机理：Nefiracetam is a nootropic of the racetam family. Nefiracetam is cognitive enhancer with an IC50 of approximately 150–200 μM for Ro 5-4864. This compound activates L/N-type calcium channels, cholinergic, monoaminergic and GABAergic systems. Nefiracetam displays potent neuroprotective action in the retinal ischemia-reperfusion model.Nootropic. Potentiates ACh currents (EC 50 = 1 nM, α4β2 receptor in cortical neurons) and NMDA currents, via interaction with the glycine binding site (EC 50 = 10 nM). Shows potent neuroprotective effects and anticonvulsant effects in vivo.

应用：Activator of L/N-type calcium channels, cholinergic, monoaminergic and GABAergic systems.

运输条件：常规运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Nefiracetam作用于Ro 5-4864引起的抽搐，是GABAergic，胆碱及单胺类的神经系统增强剂。Activator of L/N-type calcium channels, cholinergic, monoaminergic and GABAergic systems.Nefiracetam is a GABAergic, cholinergic, and monoaminergic neuronal system enhancer for Ro 5-4864-induced convulsions.Activator of L/N-type calcium channels, cholinergic, monoaminergic and GABAergic systems.

IUPAC Name：N-(2,6-dimethylphenyl)-2-(2-oxopyrrolidin-1-yl)acetamide

INCHI：InChI=1S/C14H18N2O2/c1-10-5-3-6-11(2)14(10)15-12(17)9-16-8-4-7-13(16)18/h3,5-6H,4,7-9H2,1-2H3,(H,15,17)

InChi Key：NGHTXZCKLWZPGK-UHFFFAOYSA-N

Canonical SMILES：CC1=C(C(=CC=C1)C)NC(=O)CN2CCCC2=O

Isomeric SMILES：CC1=C(C(=CC=C1)C)NC(=O)CN2CCCC2=O

WGK Germany：3

RTECS：UX9655650

PubChem CID：71157

溶解性：Soluble in DMSO (49 mg/ml at 25 °C), water (5 mg/ml at 25 °C), and ethanol (49 mg/ml at 25 °C).

熔点：151 °C

象形图：

信号词：Warning

危险声明：H319 Causes serious eye irritationH302 Harmful if swallowed

预防措施声明：P305+P351+P338,P280,P501,P264,P270,P330,P264+P265,P301+P317,P337+P317

Merck Index：6439

个人防护装备：dust mask type N95 (US), Eyeshields, Gloves

产品包装