产品名称

英文名称：Nonactin from Streptomyces griseus var griseus

同义词

nonactin、Werramycin-A、6833-84-7、Antibiotic from Actinomycete、UPJOHN 170T, high melting、5342 PFW 19、A 4426、Upjohn 170t (high melting)、TTP24WX8P7、CHEBI7614、4,13,22,31,37,38,39,40-Octaoxapentacyclo(32.2.1.1(sup 7,10).1(sup 16,19).1(sup 25,28))tetracontane-3、铵离子载体

产品性质

CAS编号：6833-84-7

分子式：C40H64O12

分子量：736.93 (for Nonactin)

PubChem编号：72519

别名：铵离子载体

英文别名：nonactin|Werramycin-A|6833-84-7|Antibiotic from Actinomycete|UPJOHN 170T, high melting|5342 PFW 19|A 4426|Upjohn 170t (high melting)|TTP24WX8P7|CHEBI7614|4,13,22,31,37,38,39,40-Octaoxapentacyclo(32.2.1.1(sup 7,10).1(sup 16,19).1(sup 25,28))tetracontane-3

规格或纯度：96%（A mixture of Nonactin, Monactin and Dinactin）

英文名称：Nonactin from Streptomyces griseus var griseus

生化机理：Nonactin is a macrotetrolide that forms complexes with alkali cations, such as potassium and sodium. Nonactin has been reported to inhibit the processing of cytoplasmic precursor proteins destined for the mitochondria. Nonactin is a uncoupler of oxidative phosphorylation.Selective K + and NH 4 + monovalent cation ionophore. Antibiotic agent. Induces cation transport across artificial membranes. Inhibits P-glycoprotein-mediated efflux of chemotherapeutic agents. Shows antibiotic effects in vivo.

储存温度：-20°C储存,充氩

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Nonactin from Streptomyces Griseus a mixture of the two homolog macrotetrolide antibiotics Nonactin, Monactin. The Nonactin is not less than 80%, ballanced by Monactin only. The mixture does not contain Dinactin, Trinactin, Tetranactin. Nonactin batches released since May 2010 are better than 95% Nonactin by NMR; detailed information is available on requestNonactin has an inhibitory effects on the P170 glycoprotein-mediated efflux of chemotherapeutic agents in multiple-drμg-resistant cancer cells. Nonactin, a natural mixture of macrotetrolides, was used in agriculture under the name trade POLYNACTIN. Nonactin has been reported to specifically inhibit the processing of cytoplasmic precursor proteins destined for the mitochondria. Nonactin is used in urea and ammonium specific electrodes.Nonactin from Streptomyces Griseus a mixture of the two homolog macrotetrolide antibiotics Nonactin, Monactin. The Nonactin is not less than 80%, ballanced by Monactin only. The mixture does not contain Dinactin, Trinactin, Tetranactin. Nonactin batches released since May 2010 are better than 95% Nonactin by NMR; detailed information is available on requestNonactin has an inhibitory effects on the P170 glycoprotein-mediated efflux of chemotherapeutic agents in multiple-drug-resistant cancer cells. Nonactin, a natural mixture of macrotetrolides, was used in agriculture under the name trade POLYNACTIN. Nonactin has been reported to specifically inhibit the processing of cytoplasmic precursor proteins destined for the mitochondria. Nonactin is used in urea and ammonium specific electrodes.

IUPAC Name：(1R,2R,5R,7R,10S,11S,14S,16S,19R,20R,23R,25R,28S,29S,32S,34S)-2,5,11,14,20,23,29,32-octamethyl-4,13,22,31,37,38,39,40-octaoxapentacyclo[32.2.1.17,10.116,19.125,28]tetracontane-3,12,21,30-tetrone

INCHI：InChI=1S/C40H64O12/c1-21-17-29-9-13-34(49-29)26(6)38(42)46-23(3)19-31-11-15-36(51-31)28(8)40(44)48-24(4)20-32-12-16-35(52-32)27(7)39(43)47-22(2)18-30-10-14-33(50-30)25(5)37(41)45-21/h21-36H,9-20H2,1-8H3/t21-,22+,23+,24-,25-,26+,27+,28-,29-,30+,31+,32-,33-,34+,35+,36-

InChi Key：RMIXHJPMNBXMBU-QIIXEHPYSA-N

Canonical SMILES：CC1CC2CCC(O2)C(C(=O)OC(CC3CCC(O3)C(C(=O)OC(CC4CCC(O4)C(C(=O)OC(CC5CCC(O5)C(C(=O)O1)C)C)C)C)C)C)C

Isomeric SMILES：C[C@@H]1C[C@H]2CC[C@H](O2)[C@@H](C(=O)O[C@H](C[C@@H]3CC[C@@H](O3)[C@H](C(=O)O[C@@H](C[C@H]4CC[C@H](O4)[C@@H](C(=O)O[C@H](C[C@@H]5CC[C@@H](O5)[C@H](C(=O)O1)C)C)C)C)C)C)C

WGK Germany：3

PubChem CID：72519

溶解性：Soluble in chloroform (9.80 - 10.20 mg/ml), ethanol (10 mM), DMSO (10 mg/ml), and methanol. Insoluble in water.

敏感性：对湿度敏感

熔点：145℃-146℃

个人防护装备：Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter

产品包装