产品名称

英文名称：Ketorolac tris salt

同义词

Ketorolac tromethamine、74103-07-4、Ketorolac tris salt、Toradol、Acular、Ketorolac (tromethamine salt)、Acular LS、Ketorolac tromethamine salt、Acuvail、Lixidol、Ketorolac trometamol、Acular PF、Syntex、Dolac、SPRIX、Tarasyn、Godek、Acular Preservative Free、Tromethamine、酮咯酸氨丁三醇、酮咯酸丁三醇铵盐、(±)-5-苯甲酰基-2,3-二氢-1H-吡咯里嗪-1-羧酸丁三醇氨盐

产品性质

CAS编号：74103-07-4

分子式：C15H13NO3·C4H11NO3

分子量：376.4

MDL号：MFCD00887595

PubChem编号：84003

别名：酮咯酸氨丁三醇|酮咯酸丁三醇铵盐|(±)-5-苯甲酰基-2,3-二氢-1H-吡咯里嗪-1-羧酸丁三醇氨盐

英文别名：Ketorolac tromethamine|74103-07-4|Ketorolac tris salt|Toradol|Acular|Ketorolac (tromethamine salt)|Acular LS|Ketorolac tromethamine salt|Acuvail|Lixidol|Ketorolac trometamol|Acular PF|Syntex|Dolac|SPRIX|Tarasyn|Godek|Acular Preservative Free|Tromethamine

规格或纯度：≥99%

英文名称：Ketorolac tris salt

生化机理：Non-steroidal anti-inflammatory agent and cyclooxygenase (COX) inhibitor that is relatively selective for COX-1. Inhibits the induction of nitric oxide synthase by lipopolysaccharide in a murine macrophage cell line. Part of its analgesic effect may be due to the release of opioid peptides.Selective COX-1 inhibitor. Inhibits prolieration and induces cell cycle arrest at G 0 /G 1 in vitro . Anti-inflammatory agent. Active in vivo and in vitro.

储存温度：避光,-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。有毒，请参阅SDS以获取更多信息。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Ketorolac (tromethamine salt) inhibits both isoforms of Cox in recombinant rat and human enzyme systems. Ketorolac inhibits rat Cox-1 (IC50 of 0.27 μM), rat Cox-2 (IC50 of 2.06 μM), human Cox-1 (IC50 of 1.23 μM) and human Cox-2 (IC50 of 3.50 μM). The (S) enantiomer of Ketorolac with rat Cox-1 (IC50 of 0.10 μM) is approximately twice as potent as the racemate, whereas the (R)-enantiomer (IC50 of > 100 μM) is virtually without activity. Ketorolac shows inhibition of eicosanoid formation in HEL cells (Cox-1, IC50 of 0.025 μM) and LPS-stimulated Mono Mac 6 cells (Cox-2, IC50 of 0.039 μM), but does not significantly inhibit NO accumulation in supernatants of LPS-stimulated RAW 264.7 cells up to 300 μM. Ketorolac significantly inhibits thymidine incorporation of human osteoblasts (hOBs) upon 24 hours treatment in a dose-dependent manner, and inhibits proliferation and arrests cell cycle at G0/G1 phase in hOBs.A non selective inhibitior of Cox-1 and Cox-2.

IUPAC Name：2-amino-2-(hydroxymethyl)propane-1,3-diol;5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid

INCHI：InChI=1S/C15H13NO3.C4H11NO3/c17-14(10-4-2-1-3-5-10)13-7-6-12-11(15(18)19)8-9-16(12)13;5-4(1-6,2-7)3-8/h1-7,11H,8-9H2,(H,18,19);6-8H,1-3,5H2

InChi Key：BWHLPLXXIDYSNW-UHFFFAOYSA-N

Canonical SMILES：C1CN2C(=CC=C2C(=O)C3=CC=CC=C3)C1C(=O)O.C(C(CO)(CO)N)O

Isomeric SMILES：C1CN2C(=CC=C2C(=O)C3=CC=CC=C3)C1C(=O)O.C(C(CO)(CO)N)O

WGK Germany：3

RTECS：UY7759900

PubChem CID：84003

Reaxy-Rn：6463165

溶解性：Soluble in ethanol (~7 mg/ml), DMF (~50 mg/ml), DMSO (~7 mg/ml), water (15 mg/ml), and methanol.

敏感性：对湿气、光线敏感

熔点：160-162°C

象形图：

信号词：Danger

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH301 Toxic if swallowed

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P270,P304+P340,P403+P233,P362+P364,P330,P264+P265,P301+P316,P337+P317,P332+P317,P319

Merck Index：5306

个人防护装备：Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

产品包装