产品名称

英文名称：(S)-Rasagiline

同义词

185517-74-2、(S)-N-(2-Propynyl)-2,3-dihydroinden-1-amine、TVP1022、N-PROPARGYL-1(S)-AMINOINDAN、(S)-Rasagiline、S-PAI、(1S)-N-prop-2-ynyl-2,3-dihydro-1H-inden-1-amine、MFCD09029306、TVP1022;S-PAI、Rasagiline S-isomer、Rasagiline, (S)-、4KM7HJ6CBA、N-propargyl-1-(s)am、(S)-N-(2-丙炔基)-2,3-二氢茚-1-胺

产品性质

CAS编号：185517-74-2

分子式：C12H13N

分子量：171.24

PubChem编号：5289310

别名：(S)-N-(2-丙炔基)-2,3-二氢茚-1-胺

英文别名：185517-74-2|(S)-N-(2-Propynyl)-2,3-dihydroinden-1-amine|TVP1022|N-PROPARGYL-1(S)-AMINOINDAN|(S)-Rasagiline|S-PAI|(1S)-N-prop-2-ynyl-2,3-dihydro-1H-inden-1-amine|MFCD09029306|TVP1022;S-PAI|Rasagiline S-isomer|Rasagiline, (S)-|4KM7HJ6CBA|N-propargyl-1-(s)am

规格或纯度：98% (HPLC)

英文名称：(S)-Rasagiline

生化机理：TVP1022, the S-isomer of rasagiline, an anti-Parkinson drug, appears to have the same neuroprotective activity as the R-isomer, but is 1000-fold less active as an MAO-B inhibitor. TVP1022, a neuroprotective and cytoprotective molecule, is also cardioprotective in rat models. Its activity is believed to involve stabilization of mitochondrial membrane potential, induction of Bcl-2 and activation of the PKC signalling pathway, enhancing the phosphorylation of protein kinase C and glycogen synthase kinase-3β.

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：产品介绍(S)-Rasagiline (TVP1022) 是 Rasagiline 的低活性 S-对映体形式。Rasagiline 是一种高效的不可逆的选择性线粒体单胺氧化酶 (MAO) 抑制剂，抑制大鼠脑 MAO B 和 MAO A 的IC50分别为 4.43 nM 和 412 nM。Product Describtion(S)-Rasagiline (TVP1022) is the relatively inactive S-enantiomer form of Rasagiline. Rasagiline is a highly potent selective irreversibleMAOinhibitor withIC50s of 4.43 nM and 412 nM for rat brain MAO B and A activity, respectively.

IUPAC Name：(1S)-N-prop-2-ynyl-2,3-dihydro-1H-inden-1-amine

INCHI：InChI=1S/C12H13N/c1-2-9-13-12-8-7-10-5-3-4-6-11(10)12/h1,3-6,12-13H,7-9H2/t12-/m0/s1

InChi Key：RUOKEQAAGRXIBM-LBPRGKRZSA-N

Canonical SMILES：C#CCNC1CCC2=CC=CC=C12

Isomeric SMILES：C#CCN[C@H]1CCC2=CC=CC=C12

WGK Germany：3

RTECS：NK8216500

PubChem CID：5289310

象形图：

信号词：Warning

危险声明：H302 Harmful if swallowedH400 Very toxic to aquatic life

预防措施声明：P273,P501,P264,P270,P391,P330,P301+P317

产品包装