产品名称

英文名称：Orlistat

同义词

orlistat、96829-58-2、Tetrahydrolipstatin、Xenical、Alli、Orlipastat、(-)-Tetrahydrolipstatin、Orlipastatum [INN-Latin]、Ro-18-0647、Ro 18-0647/002、Orlistat (Alli, Xenical)、(2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-2-yl (2S)-2-formamido-4-methylpentanoate、奧利司他、(-)-四氢脂抑素

产品性质

CAS编号：96829-58-2

分子式：C29H53NO5

分子量：495.75

MDL号：MFCD05662360

PubChem编号：3034010

别名：奧利司他|(-)-四氢脂抑素

英文别名：orlistat|96829-58-2|Tetrahydrolipstatin|Xenical|Alli|Orlipastat|(-)-Tetrahydrolipstatin|Orlipastatum [INN-Latin]|Ro-18-0647|Ro 18-0647/002|Orlistat (Alli, Xenical)|(2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-2-yl (2S)-2-formamido-4-methylpentanoate|

规格或纯度：>97.0%(HPLC)

英文名称：Orlistat

生化机理：奥利司他用于肥胖症研究，是一种胰脂肪酶抑制剂，在胃肠道局部起作用以抑制脂肪酶。选择性竞争性脂肪酶抑制剂（IC 50 = 0.15 µM）。显示抗增殖和抗肿瘤活性。在体外和体内具有活性。细胞可渗透的。

应用：Orlistat是一种通用的脂肪酶抑制剂，作用于人体十二指肠液的PL，IC50为122 ng/ml。

储存温度：-20°C储存,充氩

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Lipase Inhibitor, THL (Tetrahydrolipstatin), is a compound that has been shown to rapidly inactivate lipoprotein lipase (LPL). This agent has been found to bind both subunits of LPL, induce tetramerisation, and cause local conformational changes. The exception to lipase inhibition capacities of THL is phospholipase A2, which is not affected by THL. Mechanistic studies sμggest that THL inhibits the thioesterase domain of fatty acid synthase (FAS) and as a result halts cell proliferation and causes cell apoptosis. More detailed experiments show that gradually THL affects the retinoblastoma protein pathway and leads to cell-cycle arrest at G1/S boundary. Lipase Inhibitor, THL is an inhibitor of pancreatic and gastric lipase, as well as carboxyl ester lipase (CEL) and diacylglycerol lipase-α (DAGLα). Lipase Inhibitor, THL also activates caspase-3.Orlistat是一种通用的脂肪酶抑制剂，作用于人体十二指肠液的PL，IC50为122 ng/ml。Lipase Inhibitor, THL (Tetrahydrolipstatin), is a compound that has been shown to rapidly inactivate lipoprotein lipase (LPL). This agent has been found to bind both subunits of LPL, induce tetramerisation, and cause local conformational changes. The exception to lipase inhibition capacities of THL is phospholipase A2, which is not affected by THL. Mechanistic studies suggest that THL inhibits the thioesterase domain of fatty acid synthase (FAS) and as a result halts cell proliferation and causes cell apoptosis. More detailed experiments show that gradually THL affects the retinoblastoma protein pathway and leads to cell-cycle arrest at G1/S boundary. Lipase Inhibitor, THL is an inhibitor of pancreatic and gastric lipase, as well as carboxyl ester lipase (CEL) and diacylglycerol lipase-α (DAGLα). Lipase Inhibitor, THL also activates caspase-3.Orlistat is a general lipase inhibitor with IC50 of 122 ng/ml for PL from human duodenal juice

IUPAC Name：[(2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-2-yl] (2S)-2-formamido-4-methylpentanoate

INCHI：InChI=1S/C29H53NO5/c1-5-7-9-11-12-13-14-15-16-18-24(34-29(33)26(30-22-31)20-23(3)4)21-27-25(28(32)35-27)19-17-10-8-6-2/h22-27H,5-21H2,1-4H3,(H,30,31)/t24-,25-,26-,27-/m0/s1

InChi Key：AHLBNYSZXLDEJQ-FWEHEUNISA-N

Canonical SMILES：CCCCCCCCCCCC(CC1C(C(=O)O1)CCCCCC)OC(=O)C(CC(C)C)NC=O

Isomeric SMILES：CCCCCCCCCCC[C@@H](C[C@H]1[C@@H](C(=O)O1)CCCCCC)OC(=O)[C@H](CC(C)C)NC=O

WGK Germany：3

RTECS：OH3167600

PubChem CID：3034010

Reaxy-Rn：3658031

CAS Registry No.：96829-58-2

DrugBank Ligand：DB01083

Wikipedia：Tetrahydrolipstatin

ChEMBL Ligand：CHEMBL175247

PEP：orlistat

DrugCentral Ligand：1996

溶解性：Soluble in DMSO (19 mg/mL), ethanol (20 mg/mL), and DMF (20 mg/mL).

敏感性：对热敏感

比旋光度：-35° (C=1,CHCl3)

熔点：43-47°C

象形图：

危险声明：H411 Toxic to aquatic life with long lasting effectsH412 Harmful to aquatic life with long lasting effects

预防措施声明：P273,P501,P391

Merck Index：6869

个人防护装备：Eyeshields， Gloves， type N95 (US)， type P1 (EN143) respirator filter

产品包装