产品名称

英文名称：Furosemide

同义词

furosemide、54-31-9、Frusemide、Lasix、Furanthril、Furosemid、Errolon、Fusid、Aisemide、Beronald、Desdemin、Frusemin、Fuluvamide、Furanthryl、Furantril、Fursemide、Lowpstron、Macasirool、Prefemin、Rosemide、Trofurit、Fulsix、Furesis、Katlex、Lasilix、Radonna、Seguril、Transit、Lasex、呋噻米、速尿

产品性质

CAS编号：54-31-9

分子式：C12H11ClN2O5S

分子量：330.74

EC号：200-203-6

MDL号：MFCD00010549

PubChem编号：3440

别名：呋噻米|速尿

英文别名：furosemide|54-31-9|Frusemide|Lasix|Furanthril|Furosemid|Errolon|Fusid|Aisemide|Beronald|Desdemin|Frusemin|Fuluvamide|Furanthryl|Furantril|Fursemide|Lowpstron|Macasirool|Prefemin|Rosemide|Trofurit|Fulsix|Furesis|Katlex|Lasilix|Radonna|Seguril|Transit|Lasex

规格或纯度：≥98%

英文名称：Furosemide

生化机理：Furosemide is a loop diuretic inhibitor of NKCC (Na+/2Cl-/K+) cotransporter. Furosemide acts as a non-competitive antagonist at GABAA receptors with ~ 100-fold greater selectivity for α6-containing receptors than α1-containing receptors.Inhibitor of the Na + /2Cl - /K + cotransporter. Loop diuretic. Also acts as a non-competitive antagonist at GABA A receptors displaying approx. 100-fold greater selectivity for α6-containing receptors over α1-containing receptors.

应用：An inhibitor of NKCC and a GABAA receptor antagonist.Furosemide may also be used as a reference standard in determining the concentration of furosemide present in human urine samples using gas chromatography coupled with mass spectrometry (GC-MS). Furosemide may be used pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using diffuse reflectance spectroscopy. Furosemide may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by fluorimetry, spectrophotometry and high performance liquid chromatography (HPLC). These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Furosemide is a loop diuretic inhibitor of NKCC (Na+/2Cl-/K+) cotransporter. Furosemide acts as a non-competitive antagonist at GABAA receptors with ~ 100-fold greater selectivity for α6-containing receptors than α1-containing receptors.An inhibitor of NKCC and a GABAA receptor antagonist.Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Furosemide is a diuretic drug, which finds a variety of therapeutic applications such as hepatic cirrhosis, cardiac insufficiency and arterial hypertension. Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Furosemide is classified under the group of loop diuretics. It is used for the prevention of hypertension linked to renal and cardiac insufficiency. An inhibitor of NKCC and a GABAA receptor antagonist.

ALogP：2

IUPAC Name：4-chloro-2-(furan-2-ylmethylamino)-5-sulfamoylbenzoic acid

INCHI：InChI=1S/C12H11ClN2O5S/c13-9-5-10(15-6-7-2-1-3-20-7)8(12(16)17)4-11(9)21(14,18)19/h1-5,15H,6H2,(H,16,17)(H2,14,18,19)

InChi Key：ZZUFCTLCJUWOSV-UHFFFAOYSA-N

Canonical SMILES：C1=COC(=C1)CNC2=CC(=C(C=C2C(=O)O)S(=O)(=O)N)Cl

Isomeric SMILES：C1=COC(=C1)CNC2=CC(=C(C=C2C(=O)O)S(=O)(=O)N)Cl

WGK Germany：3

RTECS：CB2625000

PubChem CID：3440

DrugBank Ligand：DB00695

Wikipedia：Furosemide

ChEBI：CHEBI47426

CAS Registry No.：54-31-9

ChEMBL Ligand：CHEMBL35

RCSB PDB Ligand：FUN

PEP：furosemide

DrugCentral Ligand：1258

GPCRdb Ligand：furosemide

溶解性：Soluble in DMSO (66 mg/ml at 25 °C), ethanol (<1 mg/ml at 25 °C), water (<1 mg/ml at 25 °C), methanol (50 mg/ml), and DMF.

象形图：

信号词：Danger

危险声明：H360 May damage fertility or the unborn child

预防措施声明：P280,P405,P501,P203,P318

个人防护装备：Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

产品包装