产品名称

英文名称：Staurosporine

同义词

staurosporine、Staurosporin、62996-74-1、(+)-Staurosporine、Antibiotic 230、Antibiotic AM 2282、AM-2282、CCRIS 3272、Antibiotic AM-2282、Alkaloid AM-2282 from Streptomyces、(5S,6R,7R,9R)-6-methoxy-5-methyl-7-(methylamino)-6,7,8,9,15,16-hexahydro-5H,14H-17-oxa-4b,9a

产品性质

CAS编号：62996-74-1

分子式：C28H26N4O3

分子量：466.53

Beilstein号：1060573

MDL号：MFCD00077402

PubChem编号：44259

英文别名：staurosporine|Staurosporin|62996-74-1|(+)-Staurosporine|Antibiotic 230|Antibiotic AM 2282|AM-2282|CCRIS 3272|Antibiotic AM-2282|Alkaloid AM-2282 from Streptomyces|(5S,6R,7R,9R)-6-methoxy-5-methyl-7-(methylamino)-6,7,8,9,15,16-hexahydro-5H,14H-17-oxa-4b,9a

规格或纯度：98%

英文名称：Staurosporine

生化机理：Staurosporine (Stsp) is potent inhibitor of protein kinase C (PKC) from rat brain, exhibiting an IC50 value of 2.7 nM. It inhibits rat recombinant PKC-α approximately 100- and 1,000-fold better than PKC-δ and PKC-ζ, respectively.2 However, Stsp is non-selective in that it also inhibits the activity of a variety of other protein kinases, not only PKC isoforms. The biological effects of Stsp include cytotoxicity, relaxation of smooth muscle, and regulation of eNOS gene expression.Potent, cell-permeable, broad spectrum inhibitor of protein kinases. Kinases inhibited include protein kinase C (IC 50 = 3 nM), cAMP-dependent protein kinase (IC 50 = 8 nM) and p60v-src (IC 50 = 6 nM).

储存温度：2-8°C储存

运输条件：冰袋运输

备注：本产品以一种（或多种）包装尺寸提供，并进行冷冻干燥。因此，内含物可能会覆盖小瓶的底部或壁，因此可能不容易看到。请参阅我们的常见问题解答和信息页面以获取有关处理的更多详细信息。如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Staurosporine is a potent PKC inhibitor for PKCα, PKCγ and PKCη with IC50 of 2 nM, 5 nM and 4 nM, less potent to PKCδ (20 nM), PKCε (73 nM) and little active to PKCζ (1086 nM). Phase 3.Staurosporine is a potent PKC inhibitor for PKCα, PKCγ and PKCη with IC50 of 2 nM, 5 nM and 4 nM, less potent to PKCδ (20 nM), PKCε (73 nM) and little active to PKCζ (1086 nM). Phase 3.

IUPAC Name：(2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-16-one

INCHI：InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1

InChi Key：HKSZLNNOFSGOKW-FYTWVXJKSA-N

Canonical SMILES：CC12C(C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)NC)OC

Isomeric SMILES：C[C@@]12[C@@H]([C@@H](C[C@@H](O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)NC)OC

WGK Germany：3

PubChem CID：44259

ChEBI：CHEBI15738

CAS Registry No.：62996-74-1

ChEMBL Ligand：CHEMBL388978

BindingDB Ligand：2579

Wikipedia：Staurosporine

DrugBank Ligand：DB02010

DiscoveRx TREEspot：Staurosporine|

RCSB PDB Ligand：STU

GPCRdb Ligand：staurosporine

密度：1.56

象形图：

信号词：Danger

危险声明：H351 Suspected of causing cancerH373 Causes damage to organs through prolonged or repeated exposureH413 May cause long lasting harmful effects to aquatic lifeH302 Harmful if swallowedH228 Flammable solidH400 Very toxic to aquatic lifeH410 Very toxic to aquatic life with long lasting effectsH300 Fatal if swallowedH310 Fatal in contact with skinH340 May cause genetic defectsH350 May cause cancerH361 Suspected of damaging fertility or the unborn childH361d Suspected of damaging the unborn child

预防措施声明：P273,P280,P370+P378,P210,P302+P352,P321,P405,P501,P240,P264,P260,P281,P241,P270,P391,P330,P262,P361+P364,P203,P301+P316,P301+P317,P318,P316,P319

个人防护装备：Eyeshields,full-face particle respirator type N100 (US),Gloves,respirator cartridge type N100 (US),type P1 (EN143) respirator filter,type P3 (EN 143) respirator cartridges

产品包装