产品名称

英文名称：DMAT

同义词

DMAT、749234-11-5、4,5,6,7-TETRABROMO-N,N-DIMETHYL-1H-BENZIMIDAZOL-2-AMINE、CK2 Inhibitor II、4,5,6,7-tetrabroMo-N,N-diMethyl-1H-benzo[d]iMidazol-2-aMine、ck2inhibitor、2-Dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole、DMAT(CK2 Inhibitor)、CHEMBL376505、DIMETHY、2-二甲基氨基-4,5,6,7-四溴苯并咪唑

产品性质

CAS编号：749234-11-5

分子式：C9H7Br4N3

分子量：476.79

PubChem编号：5326976

别名：2-二甲基氨基-4,5,6,7-四溴苯并咪唑

英文别名：DMAT|749234-11-5|4,5,6,7-TETRABROMO-N,N-DIMETHYL-1H-BENZIMIDAZOL-2-AMINE|CK2 Inhibitor II|4,5,6,7-tetrabroMo-N,N-diMethyl-1H-benzo[d]iMidazol-2-aMine|ck2inhibitor|2-Dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole|DMAT(CK2 Inhibitor)|CHEMBL376505|DIMETHY

规格或纯度：≥98%

英文名称：DMAT

生化机理：Casein kinase II inhibitor II (Ck2 Inhibitor II) is a high affinity ATP-competitive inhibitor of casein kinase II. Ck2 Inhibitor II inhibits CK2 in rat liver with 1,300-fold greater selectivity for CK2 than for CK1 (IC50 = 140 nM and >200 μM respectively). Ki = 40 nM; In Jurkat human T-cell leukemia cells, Ck2 Inhibitor II does not display side effects on mitochondria polarization at concentrations up to 10 μM; Ck2 Inhibitor II is useful for in vivo studies due to cell permeability and high efficacy in cultured cells and has implications in research and treatment of neoplasia and infective diseases, in which CK2 plays a role and is highly active constitutively.

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：DMAT 是一种有效的，特异性的 CK2 抑制剂，IC50 值为 130 nMDMAT is a potent and specific CK2 inhibitor with an IC50 value of 130 nM

IUPAC Name：4,5,6,7-tetrabromo-N,N-dimethyl-1H-benzimidazol-2-amine

INCHI：InChI=1S/C9H7Br4N3/c1-16(2)9-14-7-5(12)3(10)4(11)6(13)8(7)15-9/h1-2H3,(H,14,15)

InChi Key：SLPJGDQJLTYWCI-UHFFFAOYSA-N

Canonical SMILES：CN(C)C1=NC2=C(N1)C(=C(C(=C2Br)Br)Br)Br

Isomeric SMILES：CN(C)C1=NC2=C(N1)C(=C(C(=C2Br)Br)Br)Br

PubChem CID：5326976

ChEMBL Ligand：CHEMBL376505

BindingDB Ligand：50156670

CAS Registry No.：749234-11-5

RCSB PDB Ligand：K25

溶解性：DMSO

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritation

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P304+P340,P403+P233,P362+P364,P264+P265,P337+P317,P332+P317,P319

产品包装