产品名称

英文名称：Entinostat (MS-275)

同义词

SNDX-275、SB16665、D09338、MLS006010183、AC-8968、CS-0511、MS-275, A HDAC1 and HDAC3 inhibitor、NSC756642、NSC-756642、DB11841、Carbamic acid, 3-pyridinylmethyl ester、MS-275,Entinostat, SNDX-275, MS-27-275、W-201831、N-[[4-[[(2-Aminophenyl)amino]carbonyl]phenyl]methy、恩替诺特

产品性质

CAS编号：209783-80-2

分子式：C21H20N4O3

分子量：376.41

MDL号：MFCD03453552

PubChem编号：4261

别名：恩替诺特

英文别名：SNDX-275|SB16665|D09338|MLS006010183|AC-8968|CS-0511|MS-275, A HDAC1 and HDAC3 inhibitor|NSC756642|NSC-756642|DB11841|Carbamic acid, 3-pyridinylmethyl ester|MS-275,Entinostat, SNDX-275, MS-27-275|W-201831|N-[[4-[[(2-Aminophenyl)amino]carbonyl]phenyl]methy

规格或纯度：≥98%

英文名称：Entinostat (MS-275)

生化机理：MS-275 is an inhibitor of HDAC (histone deacetylase) that preferentially inhibits HDAC1 (IC50 = 300 nM) over HDAC3 (IC50 = 8 μM). However, MS-275 does not inhibit HDAC8 (IC50 > 100 μM). MS-275 induces cyclin-dependent kinase inhibitor 1A (p21/CIP1/WAF1), slowing cell growth, differentiation, and tumor development in vivo. Recent studies sμggest that MS-275 may be particularly useful as an antineoplastic agent when combined with other drμgs, like adriamycin, inhibitors of poly (ADP-ribose) polymerase (PARP), or inhibitors of heat shock protein 90 (Hsp90).Benzamide derivative that inhibits histone deacetylase 1 (HDAC1) and HDAC2. Not active against HDAC4, 6, 8 and 10 (IC 50 >100μM). Exhibits anticancer chemotherapeutic, anti-metastatic, and neuroprotective properties.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。有毒，请参阅SDS以获取更多信息。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Entinostat (MS-275)对HDAC1和HDAC3抑制作用强于与HDACs 4， 6， 8，和10，IC50分别为0.51 μM和1.7 μM。An HDAC inhibitor shown to inhibit angiogenesis and metastasis.Entinostat (MS-275) strongly inhibits HDAC1 and HDAC3 with IC50 of 0.51 μM and 1.7 μM, compared with HDACs 4, 6, 8, and 10An HDAC inhibitor shown to inhibit angiogenesis and metastasis.

ALogP：2

IUPAC Name：pyridin-3-ylmethyl N-[[4-[(2-aminophenyl)carbamoyl]phenyl]methyl]carbamate

INCHI：InChI=1S/C21H20N4O3/c22-18-5-1-2-6-19(18)25-20(26)17-9-7-15(8-10-17)13-24-21(27)28-14-16-4-3-11-23-12-16/h1-12H,13-14,22H2,(H,24,27)(H,25,26)

InChi Key：INVTYAOGFAGBOE-UHFFFAOYSA-N

Canonical SMILES：C1=CC=C(C(=C1)N)NC(=O)C2=CC=C(C=C2)CNC(=O)OCC3=CN=CC=C3

Isomeric SMILES：C1=CC=C(C(=C1)N)NC(=O)C2=CC=C(C=C2)CNC(=O)OCC3=CN=CC=C3

WGK Germany：3

PubChem CID：4261

CAS Registry No.：209783-80-2

ChEMBL Ligand：CHEMBL27759

Wikipedia：Entinostat

溶解性：Soluble in methanol, DMSO (~30 mg/ml), DMF (~30 mg/ml), ethanol (~2 mg/ml), 11 solution of DMSOPBS(PH7.2) (~0.5 mg/ml), and water (<1 mg/ml) at 25 °C.

敏感性：对空气敏感，对热敏感

熔点：160 °C

象形图：

信号词：Danger

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH301 Toxic if swallowedH360 May damage fertility or the unborn child

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P270,P304+P340,P403+P233,P362+P364,P330,P203,P264+P265,P301+P316,P318,P337+P317,P332+P317,P319

产品包装