产品名称

英文名称：S-Nitrosylglutathione

同义词

S-nitrosoglutathione、57564-91-7、gsno、SNOG、Nitrosoglutathione、Glutathione thionitrite、(S)-2-Amino-5-(((R)-1-((carboxymethyl)amino)-3-(nitrosothio)-1-oxopropan-2-yl)amino)-5-oxopentanoic acid、N-(N-L-gamma-Glutamyl-S-nitroso-L-cysteinyl)glycine、S-NITROSO-L-G

产品性质

CAS编号：57564-91-7

分子式：C10H16N4O7S

分子量：336.32

MDL号：MFCD00214341

PubChem编号：104858

英文别名：S-nitrosoglutathione|57564-91-7|gsno|SNOG|Nitrosoglutathione|Glutathione thionitrite|(S)-2-Amino-5-(((R)-1-((carboxymethyl)amino)-3-(nitrosothio)-1-oxopropan-2-yl)amino)-5-oxopentanoic acid|N-(N-L-gamma-Glutamyl-S-nitroso-L-cysteinyl)glycine|S-NITROSO-L-G

规格或纯度：95%

英文名称：S-Nitrosylglutathione

生化机理：一氧化氮的载体。在生理pH下分解产生一氧化氮。放松平滑肌并抑制血小板聚集。

储存温度：-20°C储存,充氩

运输条件：超低温冰袋运输

备注：不稳定重新制作解决方案并立即使用。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：S-亚硝基谷胱甘肽（GSNO）是一种内源性氮氧化物，在肺和脑的细胞外液中高表达。S-Nitrosoglutathione (GSNO), an amino acid nitric oxide donor, when under physiological conditions spontaneously releases nitric oxide. In research it has been observed to selectively inhibit platelet activation and display cardioprotective effects. This product also inhibits NF-κB activation, endothelial cell proliferation and cathepsin B (cysteine proteases). GNSO has demonstrated dose dependent effects on Thymocytes by inducing apoptosis in T cells in low concentrations (< 0.6 mM), while protecting T cells from apoptosis in higher concentrations (1-2 mM).S-亚硝基谷胱甘肽（GSNO）已用作• 作为反相色谱的标准品，与化学蒸汽发生和原子荧光检测器（RPC-CVGAFS）和反相色谱荧光（RPC-FD）相结合。• 作为分光光度法和高效液相色谱（HPLC）测定的标准品。A spontaneously releasing nitric oxide donor which inhibits NFκB and platelet activation.S-Nitrosoglutathione (GSNO) is an endogenous nitrogen oxide and is highly distributed in extracellular fluids of the lung and brain.S-Nitrosoglutathione (GSNO), an amino acid nitric oxide donor, when under physiological conditions spontaneously releases nitric oxide. In research it has been observed to selectively inhibit platelet activation and display cardioprotective effects. This product also inhibits NF-κB activation, endothelial cell proliferation and cathepsin B (cysteine proteases). GNSO has demonstrated dose dependent effects on Thymocytes by inducing apoptosis in T cells in low concentrations (< 0.6 mM), while protecting T cells from apoptosis in higher concentrations (1-2 mM).S-Nitrosoglutathione (GSNO) has been used• as a standard in reversed phase chromatography coupled to chemical vapour generation and atomic fluorescence detector (RPC-CVGAFS) and reversed phase chromatography fluorimetric (RPC-FD).• as a standard in spectrophotometric and high-performance liquid chromatography (HPLC) assay.A spontaneously releasing nitric oxide donor which inhibits NFκB and platelet activation.

IUPAC Name：(2S)-2-amino-5-[[(2R)-1-(carboxymethylamino)-3-nitrososulfanyl-1-oxopropan-2-yl]amino]-5-oxopentanoic acid

INCHI：InChI=1S/C10H16N4O7S/c11-5(10(19)20)1-2-7(15)13-6(4-22-14-21)9(18)12-3-8(16)17/h5-6H,1-4,11H2,(H,12,18)(H,13,15)(H,16,17)(H,19,20)/t5-,6-/m0/s1

InChi Key：HYHSBSXUHZOYLX-WDSKDSINSA-N

Canonical SMILES：C(CC(=O)NC(CSN=O)C(=O)NCC(=O)O)C(C(=O)O)N

Isomeric SMILES：C(CC(=O)N[C@@H](CSN=O)C(=O)NCC(=O)O)[C@@H](C(=O)O)N

WGK Germany：3

RTECS：MC0558000

PubChem CID：104858

溶解性：Soluble in water (25 mg/ml), DMSO (20 mg/ml), and PBS. Insoluble in 100% ethanol, methanol, and DMF.

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritation

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P304+P340,P403+P233,P362+P364,P264+P265,P337+P317,P332+P317,P319

个人防护装备：dust mask type N95 (US), Eyeshields, Gloves

产品包装