产品名称

英文名称：Fenretinide

同义词

4-HPR、Fenretinide [USANINN]、FENRETINIDE [MART.]、NCGC00090752-12、Lopac0_000625、NCGC00090752-07、Retinoic acid p-hydroxyanilide、Fenretinida [Spanish]、FENRETINIDE [USAN]、SR-01000075917、HMS1791G21、N-(4-Hydroxyphenyl)retinamide、N-(4-hydroxyphenyl)-retinamide、H、芬维A胺

产品性质

CAS编号：65646-68-6

分子式：C26H33NO2

分子量：391.55

MDL号：MFCD00792674

PubChem编号：5288209

别名：芬维A胺

英文别名：4-HPR|Fenretinide [USANINN]|FENRETINIDE [MART.]|NCGC00090752-12|Lopac0_000625|NCGC00090752-07|Retinoic acid p-hydroxyanilide|Fenretinida [Spanish]|FENRETINIDE [USAN]|SR-01000075917|HMS1791G21|N-(4-Hydroxyphenyl)retinamide|N-(4-hydroxyphenyl)-retinamide|H

规格或纯度：≥98%

英文名称：Fenretinide

生化机理：4-Hydroxyphenylretinamide (Fenretinide) is a synthetic retinoid analog of all trans retinoic acid, which displays antiproliferative effects on cultured human breast cancer cells. In addition, 4-Hydroxyphenylretinamide functions as a selective activator of RAR (retinoid receptors). Studies involving lymphoid and myeloid malignant cell lines indicate that 4-Hydroxyphenylretinamide can induce apoptosis and reduce cell growth. These studies sμggest that 4-Hydroxyphenylretinamide and all trans retanoic acid may bind to two different receptors to induce apoptosis.Synthetic retinoid agonist. Anticancer, apoptotic, antioxidant activity in vitro and in vivo . Demonstrates a long half-life in vivo .

应用：An agonist displaying activity at retinoid receptors

储存温度：-20°C储存,充氩

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Fenretinide (4-HPR)是合成的维甲酸衍生物，能结合维甲酸受体（RAR）。An agonist displaying activity at retinoid receptorsFenretinide (4-HPR) is a synthetic retinoid deriverative. 4-HBR is shown to exhibit binding to the retinoic acid receptors (RAR) at concentrations necessary to induce cell death. An agonist displaying activity at retinoid receptors

IUPAC Name：(2E,4E,6E,8E)-N-(4-hydroxyphenyl)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenamide

INCHI：InChI=1S/C26H33NO2/c1-19(11-16-24-21(3)10-7-17-26(24,4)5)8-6-9-20(2)18-25(29)27-22-12-14-23(28)15-13-22/h6,8-9,11-16,18,28H,7,10,17H2,1-5H3,(H,27,29)/b9-6+,16-11+,19-8+,20-18+

InChi Key：AKJHMTWEGVYYSE-FXILSDISSA-N

Canonical SMILES：CC1=C(C(CCC1)(C)C)C=CC(=CC=CC(=CC(=O)NC2=CC=C(C=C2)O)C)C

Isomeric SMILES：CC1=C(C(CCC1)(C)C)/C=C/C(=C/C=C/C(=C/C(=O)NC2=CC=C(C=C2)O)/C)/C

WGK Germany：3

RTECS：VH6420000

PubChem CID：5288209

溶解性：Soluble in DMSO (25 mg/ml), ethanol (25 mg/ml)), chloroform, and acetone (easily soluble).

敏感性：对热和空气敏感

熔点：172 °C

象形图：

信号词：Danger

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH302 Harmful if swallowedH312 Harmful in contact with skinH332 Harmful if inhaledH360 May damage fertility or the unborn child

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P270,P304+P340,P403+P233,P362+P364,P330,P203,P264+P265,P301+P317,P318,P317,P337+P317,P332+P317,P319

Merck Index：3998

个人防护装备：Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

产品包装