产品名称

英文名称：Adefovir

同义词

Phosphonic acid, ((2-6-amino-9H-purin-9-YL)ethoxy)methyl、ADEFOVIR [WHO-DD]、DB13868、((2-6-amino-9H-purin-9-yl) ethoxy) methyl)- phosphonic acid.、106941-25-7 (free acid)、BA166179、HY-B1826、AC-012、GS-0393、2-(6-aminopurin-9-yl)ethoxymethylphosphonic acid、6GQP9、阿德福韦

产品性质

CAS编号：106941-25-7

分子式：C8H12N5O4P

分子量：273.19

MDL号：MFCD00866943

PubChem编号：60172

别名：阿德福韦

英文别名：Phosphonic acid, ((2-6-amino-9H-purin-9-YL)ethoxy)methyl|ADEFOVIR [WHO-DD]|DB13868|((2-6-amino-9H-purin-9-yl) ethoxy) methyl)- phosphonic acid.|106941-25-7 (free acid)|BA166179|HY-B1826|AC-012|GS-0393|2-(6-aminopurin-9-yl)ethoxymethylphosphonic acid|6GQP9

规格或纯度：98% (HPLC)

英文名称：Adefovir

生化机理：核苷酸类似物逆转录酶抑制剂（K i = 100 nM，HBV DNA聚合酶）。抗病毒剂。cAMP模拟。MRP4底物。在体内显示出对乙型肝炎的抗复制作用。口服具有活性

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Adefovir (GS-0393) is an adenosine monophosphate analog antiviral agent that after intracellular conversion to Adefovir diphosphate inhibits HBV DNA polymerase. Adefovir has an IC50 of 0.7 μM against HBV in the HepG2.2.15 cell line. Adefovir has good antiviral activity against several viruses, including HBV and herpesviruses.Adefovir (GS-0393) is an adenosine monophosphate analog antiviral agent that after intracellular conversion to Adefovir diphosphate inhibits HBV DNA polymerase. Adefovir has an IC50 of 0.7 μM against HBV in the HepG2.2.15 cell line. Adefovir has good antiviral activity against several viruses, including HBV and herpesviruses.

ALogP：-2

IUPAC Name：2-(6-aminopurin-9-yl)ethoxymethylphosphonic acid

INCHI：InChI=1S/C8H12N5O4P/c9-7-6-8(11-3-10-7)13(4-12-6)1-2-17-5-18(14,15)16/h3-4H,1-2,5H2,(H2,9,10,11)(H2,14,15,16)

InChi Key：SUPKOOSCJHTBAH-UHFFFAOYSA-N

Canonical SMILES：C1=NC(=C2C(=N1)N(C=N2)CCOCP(=O)(O)O)N

Isomeric SMILES：C1=NC(=C2C(=N1)N(C=N2)CCOCP(=O)(O)O)N

WGK Germany：3

RTECS：SZ6563500

PubChem CID：60172

溶解性：solubility 0.1 M NaOH ≥5 mg/mL;

象形图：

信号词：Danger

危险声明：H301 Toxic if swallowed

预防措施声明：P321,P405,P501,P264,P270,P330,P301+P316

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