产品名称

英文名称：Rolipram

同义词

rolipram、61413-54-5、(R,S)-rolipram、ZK 62711、Rolipramum [Latin]、(+/-)-Rolipram、4-(3-(cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one、4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone、Rolipramum、4-[3-(cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one、A、咯利普兰、4-[3-(环戊氧基)-4-甲氧基苯基]-2-吡咯烷酮

产品性质

CAS编号：61413-54-5

分子式：C16H21NO3

分子量：275.34

EC号：262-771-1

MDL号：MFCD00270906

PubChem编号：5092

别名：咯利普兰|4-[3-(环戊氧基)-4-甲氧基苯基]-2-吡咯烷酮

英文别名：rolipram|61413-54-5|(R,S)-rolipram|ZK 62711|Rolipramum [Latin]|(+/-)-Rolipram|4-(3-(cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one|4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone|Rolipramum|4-[3-(cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one|A

规格或纯度：≥97%

英文名称：Rolipram

生化机理：Rolipram is a selective, cell-permeable inhibitor of cAMP-specific PDE (phosphodiesterase) (PDE4, IC50=1 μM). This compound has been shown to inhibit PDE4 activity in human cavernosal tissue, which interrupts the signal transduction pathway of erectile response. Rolipram promotes apoptosis in HL60 cells throμgh a cAMP-independent mechanism and has been shown to enhance neuronal survival. Rolipram is an inhibitor of PDE4A1 and PDE4B.Selective cAMP-specific phosphodiesterase PDE4 inhibitor (IC 50 values are 1.1 and 0.17 μM for inhibition of mouse PDE4A1 and PDE4B, respectively)

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：卖完停产，不再备货。如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：A selective, cell permeable inhibitor of cAMP-specific phosphodiesterase (PDE4).Rolipram enhances tissue protection, anatomical repair and functional recovery. It is used to treat asthma, arthritis, Huntington′s disease and multiple sclerosis. Rolipram inhibits injury-induced reductions in cyclic AMP, which is associated with acute central nervous system injury. It functions as an antidepressant, stimulates neurite outgrowth and axonal regeneration in the presence of myelin inhibitors.A selective, cell permeable inhibitor of cAMP-specific phosphodiesterase (PDE4).

ALogP：2.2

IUPAC Name：4-(3-cyclopentyloxy-4-methoxyphenyl)pyrrolidin-2-one

INCHI：InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)

InChi Key：HJORMJIFDVBMOB-UHFFFAOYSA-N

Canonical SMILES：COC1=C(C=C(C=C1)C2CC(=O)NC2)OC3CCCC3

Isomeric SMILES：COC1=C(C=C(C=C1)C2CC(=O)NC2)OC3CCCC3

WGK Germany：3

RTECS：UY5749237

关联CAS：61413-54-5

PubChem CID：5092

NSC Number：760125

MeSH Entry Terms：Rolipram;ZK 62711;ZK-62711;ZK62711

CAS Registry No.：61413-54-5

DrugBank Ligand：DB04149, DB03606

Wikipedia：Rolipram

ChEBI：CHEBI104872

ChEMBL Ligand：CHEMBL63

溶解性：Soluble in water (0.2 mg/mL ), DMSO (7.3 mg/ml ), ethanol (7 mg/ml warm), DMF (~10 mg/ml ), DMFPBS (pH 7.2, 19) (~0.5 mg/ml ), and acetone (25 mg/ml).

敏感性：对热敏感

熔点：130-134°C

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH302 Harmful if swallowed

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P270,P304+P340,P403+P233,P362+P364,P330,P264+P265,P301+P317,P337+P317,P332+P317,P319

Merck Index：8251

个人防护装备：dust mask type N95 (US), Eyeshields, Gloves

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