产品名称

英文名称：Temozolomide

同义词

temozolomide、85622-93-1、Methazolastone、Temodar、Temodal、Temozolamide、3-methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide、Sch 52365、CCRG-81045、Temozolomidum [Latin]、Temozolodida [Spanish]、Temozolomidum、CCRG 81045、NSC 362856、Sch-52365、M&、替莫唑胺、3,4-二氢-3-甲基-4-氧代咪唑并[5,1-d]-1,2,3,5-四嗪-8-甲酰胺、8-氨甲酰-3-甲基咪唑[5,1-d]-1,2,3,5-四嗪-4(3H)-酮,、3-甲基-4-氧代-3,4-二氢咪唑并[5,1-d][1,2,3,5]四嗪-8-甲酰胺、4-甲基-5-氧代-2,3,4,6,8-五氮杂双环[4.3.0]壬基-2,7,9-三烯-9-甲酰胺

产品性质

CAS编号：85622-93-1

分子式：C6H6N6O2

分子量：194.15

MDL号：MFCD00866492

PubChem编号：5394

别名：替莫唑胺|3,4-二氢-3-甲基-4-氧代咪唑并[5,1-d]-1,2,3,5-四嗪-8-甲酰胺|8-氨甲酰-3-甲基咪唑[5,1-d]-1,2,3,5-四嗪-4(3H)-酮,|3-甲基-4-氧代-3,4-二氢咪唑并[5,1-d][1,2,3,5]四嗪-8-甲酰胺|4-甲基-5-氧代-2,3,4,6,8-五氮杂双环[4.3.0]壬基-2,7,9-三烯-9-甲酰胺

英文别名：temozolomide|85622-93-1|Methazolastone|Temodar|Temodal|Temozolamide|3-methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide|Sch 52365|CCRG-81045|Temozolomidum [Latin]|Temozolodida [Spanish]|Temozolomidum|CCRG 81045|NSC 362856|Sch-52365|M&

规格或纯度：≥98% (HPLC)

英文名称：Temozolomide

生化机理：Temozolomide is an antitumor, antiangiogenic compound that has been shown to work by alkylating DNA, typically throμgh addition of a methyl group to guanine in genomic DNA. The efficacy of this compound is dependent on its ability to methylate the DNA, thus triggering apoptosis; however, some cells are able to repair this damage via the enzymes O-6-methylguanine-DNA methyltransferase (MGMT). As a enzyme. Research has also been conducted to determine whether MGMT inhibitors such as O-6-benzylguanine might help to increase the efficacy of temozolomide. Furthermore, temozolomide has been implicated in causing arrest at the G2/M cell cycle checkpoint, which might also play a role in its cytotoxicity.DNA alkylating/methylating chemotherapeutic agent. Inhibits DNA replication. Anti-cancer and apoptotic activity in vitro and in vivo . Crosses the blood-brain barrier.

储存温度：2-8°C储存,充氩

运输条件：冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Temozolomide是一种DNA损伤诱导剂。An apoptosis inducer which causes arrest at the G2/M cell cycle checkpoint.Temozolomide is a DNA damage inducer.An apoptosis inducer which causes arrest at the G2/M cell cycle checkpoint.

ALogP：-1.1

IUPAC Name：3-methyl-4-oxoimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide

INCHI：InChI=1S/C6H6N6O2/c1-11-6(14)12-2-8-3(4(7)13)5(12)9-10-11/h2H,1H3,(H2,7,13)

InChi Key：BPEGJWRSRHCHSN-UHFFFAOYSA-N

Canonical SMILES：CN1C(=O)N2C=NC(=C2N=N1)C(=O)N

Isomeric SMILES：CN1C(=O)N2C=NC(=C2N=N1)C(=O)N

WGK Germany：3

RTECS：NJ5927050

PubChem CID：5394

Reaxy-Rn：5547136

DrugBank Ligand：DB00853

CAS Registry No.：85622-93-1

ChEMBL Ligand：CHEMBL810

Wikipedia：Temozolomide

PEP：temozolomide

DrugCentral Ligand：2589

溶解性：Soluble in water (5 mg/ml at 25 °C), DMSO (39 mg/ml at 25 °C), and ethanol (<1 mg/ml at 25 °C).

敏感性：对热敏感

熔点：206 °C(dec.)

象形图：

信号词：Danger

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH341 Suspected of causing genetic defectsH351 Suspected of causing cancerH302 Harmful if swallowedH300 Fatal if swallowedH372 Causes damage to organs through prolonged or repeated exposureH360 May damage fertility or the unborn childH340 May cause genetic defectsH350 May cause cancer

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P260,P281,P271,P270,P304+P340,P403+P233,P362+P364,P330,P203,P264+P265,P301+P316,P301+P317,P318,P337+P317,P332+P317,P319

Merck Index：9139

个人防护装备：Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

产品包装