产品名称

英文名称：Granisetron

同义词

granisetron、109889-09-0、Sancuso、Sustol、Kevatril、Granisetronum、APF530、Kytril、BRL-43694、1-methyl-N-[(1S,5R)-9-methyl-9-azabicyclo[3.3.1]nonan-3-yl]indazole-3-carboxamide、CHEBI5537、BRL 43694、APF 530、WZG3J2MCOL、1-methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.

产品性质

CAS编号：109889-09-0

分子式：C18H24N4O

分子量：312.41

PubChem编号：5284566

英文别名：granisetron|109889-09-0|Sancuso|Sustol|Kevatril|Granisetronum|APF530|Kytril|BRL-43694|1-methyl-N-[(1S,5R)-9-methyl-9-azabicyclo[3.3.1]nonan-3-yl]indazole-3-carboxamide|CHEBI5537|BRL 43694|APF 530|WZG3J2MCOL|1-methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.

规格或纯度：≥98.0%

英文名称：Granisetron

生化机理：DescriptionIC50 Value 17uM (GR reduced 5-HT-evoked contractions) [1]Granisetron is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy.in vitro In rat forestomach GR reduced 5-HT-evoked contractions at IC50 17 /- 6 uM. In isolated rabbit heart, GR 0.003-0.03 nM dose-dependently reduced s-HT tachycardia; at high levels GR reduced submaximal and maximal responses to 5-HT [1].in vivo Leukocyte accumulation was dose-dependently inhibited by granisetron both at 6 and 72 h after induction of inflammation. Granisetron increased PGE(2) level at a lower dose (50 microg/pouch) but higher doses (100 and 200 microg/pouch) inhibited the release. At the same time, TNFalpha production was decreased by the lower dose and increased by higher doses of granisetron in a reciprocal fashion [2]. The GTDS displayed non-inferiority to oral granisetron complete control was achieved by 60% of patients in the GTDS group, and 65% in the oral granisetron group (treatment difference, -5%; 95% confidence interval, -13-3). Both treatments were well tolerated, the most common adverse event being constipation [3].Clinical trial Effect of External Heat on a Transdermal Granisetron Patch in Pharmacokinetics (PK) of Healthy Subjects. Phase 1

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：Granisetron is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy.Granisetron is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy.

IUPAC Name：1-methyl-N-[(1R,5S)-9-methyl-9-azabicyclo[3.3.1]nonan-3-yl]indazole-3-carboxamide

INCHI：InChI=1S/C18H24N4O/c1-21-13-6-5-7-14(21)11-12(10-13)19-18(23)17-15-8-3-4-9-16(15)22(2)20-17/h3-4,8-9,12-14H,5-7,10-11H2,1-2H3,(H,19,23)/t12?,13-,14+

InChi Key：MFWNKCLOYSRHCJ-AGUYFDCRSA-N

Canonical SMILES：CN1C2CCCC1CC(C2)NC(=O)C3=NN(C4=CC=CC=C43)C

Isomeric SMILES：CN1[C@@H]2CCC[C@H]1CC(C2)NC(=O)C3=NN(C4=CC=CC=C43)C

PubChem CID：5284566

DrugBank Ligand：DB00889

Wikipedia：Granisetron

CAS Registry No.：109889-09-0

溶解性：DMSO11 mg/mL

象形图：

信号词：Warning

危险声明：H319 Causes serious eye irritationH412 Harmful to aquatic life with long lasting effectsH302 Harmful if swallowed

预防措施声明：P305+P351+P338,P273,P280,P501,P264,P270,P330,P264+P265,P301+P317,P337+P317

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