产品名称

英文名称：1H-[1，2，4]Oxadiazolo[4，3-a]quinoxalin-1-one

同义词

41443-28-1、1h-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one、ODQ、[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one、S57V2NMV38、1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one、1H-(1,2,4)Oxadiazolo-(4,3,A)quinoxalin-1-one、SR-01000075519、1-H-[1,2,4]Oxadiazolo-[4,3,2]quinoxalin-

产品性质

CAS编号：41443-28-1

分子式：C9H5N3O2

分子量：187.16

MDL号：MFCD00792620

PubChem编号：1456

英文别名：41443-28-1|1h-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one|ODQ|[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one|S57V2NMV38|1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one|1H-(1,2,4)Oxadiazolo-(4,3,A)quinoxalin-1-one|SR-01000075519|1-H-[1,2,4]Oxadiazolo-[4,3,2]quinoxalin-

规格或纯度：≥98%

英文名称：1H-[1，2，4]Oxadiazolo[4，3-a]quinoxalin-1-one

生化机理：一氧化氮敏感性鸟苷酸环化酶的选择性有效抑制剂。

应用：A selective and potent sGC (soluble guanylyl cyclase) inhibitor.

运输条件：常规运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：ODQ is a selective and potent GCS (soluble guanylyl cyclase, sGC) inhibitor that binds competitively with nitric oxide. The GCS (sGC) serves as a receptor for nitric oxide, which is involved in the production of cyclic guanosine monophosphate (cGMP). In prostate cancer cell studies, ODQ induced caspase-3, enhanced cell death, and blocked cell migration. Inhibition of GCS (sGC) throμgh ODQ results in blocking the actions of nitric oxide on vascular and platelet smooth muscle.A selective and potent sGC (soluble guanylyl cyclase) inhibitor.ODQ is a selective and potent GCS (soluble guanylyl cyclase, sGC) inhibitor that binds competitively with nitric oxide. The GCS (sGC) serves as a receptor for nitric oxide, which is involved in the production of cyclic guanosine monophosphate (cGMP). In prostate cancer cell studies, ODQ induced caspase-3, enhanced cell death, and blocked cell migration. Inhibition of GCS (sGC) through ODQ results in blocking the actions of nitric oxide on vascular and platelet smooth muscle.A selective and potent sGC (soluble guanylyl cyclase) inhibitor.

PubChem SID：488179621

PubChem SID url：https//pubchem.ncbi.nlm.nih.gov/substance/488179621

IUPAC Name：[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one

INCHI：InChI=1S/C9H5N3O2/c13-9-12-7-4-2-1-3-6(7)10-5-8(12)11-14-9/h1-5H

InChi Key：LZMHWZHOZLVYDL-UHFFFAOYSA-N

Canonical SMILES：C1=CC=C2C(=C1)N=CC3=NOC(=O)N23

Isomeric SMILES：C1=CC=C2C(=C1)N=CC3=NOC(=O)N23

WGK Germany：3

PubChem CID：1456

CAS Registry No.：41443-28-1

ChEMBL Ligand：CHEMBL598952

溶解性：Soluble in ethanol (1.2 mg/ml), DMSO (5 mg/ml), chloroform (10 mg/ml), acetonitrile (20 mg/ml), ethyl acetate, DMF (~30 mg/ml), and 11 solution of DMFPBS(pH7.2) (~100 μg/ml). Insoluble in water.

敏感性：对热敏感

熔点：162 °C

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritation

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P304+P340,P403+P233,P362+P364,P264+P265,P337+P317,P332+P317,P319

产品包装