产品名称

英文名称：Ozagrel

同义词

Ozagrelum、Ozagrelum [Latin]、DTXSID6048547、2-Propenoic acid, 3-(4-(1H-imidazol-1-ylmethyl)phenyl)-, (E)-、Cataclot (TN)、HMS3884N21、DB12017、SBI-0207081.P001、AB00514722、L256JB984D、BDBM50017896、SW197369-5、2-Propenoic acid, 3-[4-(1H-imidazol-1-ylmethyl)phenyl]-、奥扎格雷

产品性质

CAS编号：82571-53-7

分子式：C13H12N2O2

分子量：228.25

PubChem编号：5282440

别名：奥扎格雷

英文别名：Ozagrelum|Ozagrelum [Latin]|DTXSID6048547|2-Propenoic acid, 3-(4-(1H-imidazol-1-ylmethyl)phenyl)-, (E)-|Cataclot (TN)|HMS3884N21|DB12017|SBI-0207081.P001|AB00514722|L256JB984D|BDBM50017896|SW197369-5|2-Propenoic acid, 3-[4-(1H-imidazol-1-ylmethyl)phenyl]-

规格或纯度：≥98%

英文名称：Ozagrel

生化机理：Ozagrel, an antithrombic drμg, is a potent and selective TXA Synthase (thromboxane A2) inhibitor highly active in human platelets. Found to induce apoptosis in T24 and TCC-SUP bladder cancer cells. Ozagrel improved locomotor activity and coordination in ischemia-reperfusion injured mice models and has potential therapeutic usage for stroke. Reported to inhibit pulmonary thromboxane B2 delivery blocking the increase in systemic vascular resistance. Also shown to inhibit phenolase activities of mushroom tyrosinase.

储存温度：2-8°C储存

运输条件：冰袋运输

备注：50mg、250mg、10mg卖完停产，不再备货

产品介绍：Ozagrel是一种有效的，选择性的血栓素A2合成酶抑制剂，IC50为4 nM。A potent and selective thromboxane A2 inhibitor.Ozagrel is a potent and selective thromboxane A2 synthetase inhibitor with an IC50 of 4 nM.A potent and selective thromboxane A2 inhibitor.

ALogP：1.6

IUPAC Name：(E)-3-[4-(imidazol-1-ylmethyl)phenyl]prop-2-enoic acid

INCHI：InChI=1S/C13H12N2O2/c16-13(17)6-5-11-1-3-12(4-2-11)9-15-8-7-14-10-15/h1-8,10H,9H2,(H,16,17)/b6-5+

InChi Key：SHZKQBHERIJWAO-AATRIKPKSA-N

Canonical SMILES：C1=CC(=CC=C1CN2C=CN=C2)C=CC(=O)O

Isomeric SMILES：C1=CC(=CC=C1CN2C=CN=C2)/C=C/C(=O)O

PubChem CID：5282440

ChEMBL Ligand：CHEMBL11662

BindingDB Ligand：50017896

CAS Registry No.：82571-53-7

DrugCentral Ligand：2043

溶解性：Soluble in DMSO (10 mg/ml), DMF (5 mg/ml), 11 DMSOPBS(pH 7.2) (~1 mg/ml), and ethanol (≥1 mg/ml). Insoluble in water.

熔点：223-224°C

产品包装