产品名称

英文名称：Methotrexate hydrate

同义词

Methotrexate hydrate、Methotrexate monohydrate、133073-73-1、Methotrexate hydrate(1x)、6745-93-3、Methotrexate (monohydrate)、84DMZ3IHO0、(2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid;hydrate、L-Glutamic acid, N-[4-[[(2、胺甲喋呤水合物、对-[(2,4-二氨基喋啶-6)-N-甲基甲氨基]苯甲酰谷氨酸 水合物、L-氨甲喋呤 水合物、MTX 水合物、氟安定 水合物, 氨甲叶酸 水合物、氨甲喋呤 水合物、N-[4-[[(2,4-二氨基-6-蝶啶)甲基]甲氨基]苯甲酰]-L-谷氨酸 水合物

产品性质

CAS编号：133073-73-1

分子式：C20H22N8O5·xH2O

分子量：454.44 (anhydrous basis)

Beilstein号：70669

MDL号：MFCD00064370

PubChem编号：165528

别名：胺甲喋呤水合物|对-[(2,4-二氨基喋啶-6)-N-甲基甲氨基]苯甲酰谷氨酸 水合物|L-氨甲喋呤 水合物|MTX 水合物|氟安定 水合物, 氨甲叶酸 水合物|氨甲喋呤 水合物|N-[4-[[(2,4-二氨基-6-蝶啶)甲基]甲氨基]苯甲酰]-L-谷氨酸 水合物

英文别名：Methotrexate hydrate|Methotrexate monohydrate|133073-73-1|Methotrexate hydrate(1x)|6745-93-3|Methotrexate (monohydrate)|84DMZ3IHO0|(2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid;hydrate|L-Glutamic acid, N-[4-[[(2

规格或纯度：99%

英文名称：Methotrexate hydrate

生化机理：Methotrexate trihydrate is the hydrated form of Methotrexate. Methotrexate is a cell cycle arresting agent with varying effects. Methotrexate has been reported to arrest the cell cycle in late G1/S thus leading to the inhibition of the synthesis of DNA, RNA, thymidylates, and proteins. The main mechanism of action is reported to involve the inhibition of enzymes involved in purine metabolism which leads to the accumulation of adenosine or the suppression of intercellular adhesion molecule expression by T cells. Additionally, this compound has been observed to inhibit DHFR. Methotrexate has also been shown to modulate inflammation by promoting adenosine release or inhibiting transmethylation reactions. Methotrexate was also noted to decrease IL-1 production in adherent splenic cells. Additionally offered as, Methotrexate

储存温度：-20°C储存,充氩

运输条件：超低温冰袋运输

产品介绍：产品介绍叶酸拮抗剂，二羟基叶酸还原酶（dihydrofolate reductase）抑制剂。产品应用二氢叶酸还原酶的有效抑制剂 和抗肿瘤的研究试剂。 用于抑制二氢叶酸还原酶在DHFR蛋白表达系统中的表达。还可有效治疗耐甲氧嘧啶的 间日 疟原虫。也显示免疫抑制作用，如类风湿关节炎。A cell cycle arrest agent that inhibits DHFR and modulates inflammation

ALogP：-1.8

IUPAC Name：(2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid;hydrate

INCHI：InChI=1S/C20H22N8O5.H2O/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30;/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27);1H2/t13-;/m0./s1

InChi Key：FPJYMUQSRFJSEW-ZOWNYOTGSA-N

Canonical SMILES：CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O.O

Isomeric SMILES：CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)O)C(=O)O.O

关联CAS：59-05-2；6745-93-3

PubChem CID：165528

UN Number：1544

溶解性：易溶于稀碱、酸或碱金属的碳酸盐溶液,微溶于稀盐酸,几乎不溶于水、乙醇、氯仿、乙醚.

密度：1.536

敏感性：对光和湿度敏感

比旋光度：21 ° (C=0.1, 1N NaOH)

熔点：205℃

象形图：

信号词：Danger

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH301 Toxic if swallowedH360 May damage fertility or the unborn child

预防措施声明：P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P270,P362+P364,P330,P203,P264+P265,P301+P316,P318,P337+P317,P332+P317

Merck Index：5985

产品包装