产品名称

英文名称：Sildenafil

同义词

SMR004703325、Sildenafil- Bio-X、DTXCID003579、G04BE03、HSDB 7305、Spectrum3_001892、UK-92480、sildenafilum、SpecPlus_000798、UNII-3M7OB98Y7H、5-{2-ETHOXY-5-[(4-METHYLPIPERAZIN-1-YL)SULFONYL]PHENYL}-1-METHYL-3-PROPYL-1H,6H,7H-PYRAZOLO[4,3-D]PYRIMIDIN-7-ONE、AC-938、H、西地那非

产品性质

CAS编号：139755-83-2

分子式：C22H30N6O4S

分子量：474.58

PubChem编号：135398744

别名：西地那非

英文别名：SMR004703325|Sildenafil- Bio-X|DTXCID003579|G04BE03|HSDB 7305|Spectrum3_001892|UK-92480|sildenafilum|SpecPlus_000798|UNII-3M7OB98Y7H|5-{2-ETHOXY-5-[(4-METHYLPIPERAZIN-1-YL)SULFONYL]PHENYL}-1-METHYL-3-PROPYL-1H,6H,7H-PYRAZOLO[4,3-D]PYRIMIDIN-7-ONE|AC-938|H

规格或纯度：≥98.0%

英文名称：Sildenafil

生化机理：Sildenafil is a selective inhibitor of the type 5 cGMP phosphodiesterase (PDE5 inhibitor) which catalyzes the hydrolysis of 3',5'-cyclic guanosine monophosphate (cGMP). As a PDE5 inhibitor, Sildenafil has been reported to enhance neuro-, synapto- and angiogenesis in rat models of stroke and also is reported to be a mild vasodilator. Sildenafil has also been shown to prevent indomethacin-induced small intestinal ulceration formation throμgh an NO/cGMP- dependent mechanism.

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：Sildenafil是磷酸二酯酶5（PDE-5）抑制剂，IC50为5.22 nM，可能是最好的可作用于勃起功能紊乱的化合物。A type 5 cGMP phosphodiesterase (PDE5) inhibitor and vasodilator.Sildenafil, one of the selective phosphodiesterase-5 (PDE5) inhibitors(IC50= 5.22 nM), is considered the best treatment for erectile dysfunction.A type 5 cGMP phosphodiesterase (PDE5) inhibitor and vasodilator.

IUPAC Name：5-[2-ethoxy-5-(4-methylpiperazin-1-yl)sulfonylphenyl]-1-methyl-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-7-one

INCHI：InChI=1S/C22H30N6O4S/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29)

InChi Key：BNRNXUUZRGQAQC-UHFFFAOYSA-N

Canonical SMILES：CCCC1=NN(C2=C1N=C(NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)C)OCC)C

Isomeric SMILES：CCCC1=NN(C2=C1N=C(NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)C)OCC)C

PubChem CID：135398744

DrugBank Ligand：DB00203

Wikipedia：Sildenafil

CAS Registry No.：139755-83-2

ChEBI：CHEBI9139

ChEMBL Ligand：CHEMBL192

RCSB PDB Ligand：VIA

PEP：sildenafil

DrugCentral Ligand：2441

溶解性：Soluble in DMSO, methanol, and water (3.5 mg/mL).

象形图：

信号词：Warning

危险声明：H319 Causes serious eye irritationH412 Harmful to aquatic life with long lasting effectsH302 Harmful if swallowed

预防措施声明：P305+P351+P338,P273,P280,P501,P264,P270,P330,P264+P265,P301+P317,P337+P317

产品包装