产品名称

英文名称：KN-93

同义词

kn-93、139298-40-1、KN 93、Methoxybenzene-sulfonamide、KN93、(E)-N-(2-(((3-(4-Chlorophenyl)allyl)(methyl)amino)methyl)phenyl)-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide、1188890-40-5、N-[2-[[[(E)-3-(4-chlorophenyl)prop-2-enyl]-methylamino]methyl]phenyl]-N-(2

产品性质

CAS编号：139298-40-1

分子式：C26H29ClN2O4S

分子量：599.03

MDL号：MFCD00236424

PubChem编号：5312122

英文别名：kn-93|139298-40-1|KN 93|Methoxybenzene-sulfonamide|KN93|(E)-N-(2-(((3-(4-Chlorophenyl)allyl)(methyl)amino)methyl)phenyl)-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide|1188890-40-5|N-[2-[[[(E)-3-(4-chlorophenyl)prop-2-enyl]-methylamino]methyl]phenyl]-N-(2

规格或纯度：≥98%

英文名称：KN-93

生化机理：KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase (Ki = 370 nM). KN-93 inhibits histamine-induced aminopyrine uptake in parietal cells (IC50 = 300 nM). KN-93 has been used to implicate roles for CaMKII in Ca2+-induced Ca2+ release in cardiac myocytes, constitutive phosphorylation of 5-lipoxygenase in 3T3 cells, and Ca2+-dependent activation of HIF-1α in colon cancer cell.Potent, cell-permeable CaM kinase II inhibitor (IC 50 = 370 nM). Potent voltage gated K + channel blocker (IC 50 = 307 nM, K V 1.5). Analog of water soluble KN-93 . Suppresses early afterdepolarization. Induces ROS generation and apoptosis.

储存温度：2-8°C储存

运输条件：冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：KN-93是钙离子/钙调蛋白依赖激酶II（CaMKII）抑制剂，能竞争性阻断钙调蛋白与对应激酶的结合，Ki为370 nM。An effective inhibitor of CaMKII phosphorylating activityKN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase (Ki = 370 nM). An effective inhibitor of CaMKII phosphorylating activity

IUPAC Name：N-[2-[[[(E)-3-(4-chlorophenyl)prop-2-enyl]-methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide

INCHI：InChI=1S/C26H29ClN2O4S/c1-28(17-5-6-21-9-11-23(27)12-10-21)20-22-7-3-4-8-26(22)29(18-19-30)34(31,32)25-15-13-24(33-2)14-16-25/h3-16,30H,17-20H2,1-2H3/b6-5+

InChi Key：LLLQTDSSHZREGW-AATRIKPKSA-N

Canonical SMILES：CN(CC=CC1=CC=C(C=C1)Cl)CC2=CC=CC=C2N(CCO)S(=O)(=O)C3=CC=C(C=C3)OC

Isomeric SMILES：CN(C/C=C/C1=CC=C(C=C1)Cl)CC2=CC=CC=C2N(CCO)S(=O)(=O)C3=CC=C(C=C3)OC

WGK Germany：3

PubChem CID：5312122

ChEMBL Ligand：CHEMBL155333

CAS Registry No.：139298-40-1

RCSB PDB Ligand：KN9

溶解性：DMSO > 25 mg/ml Ethanol > 25 mg/ml

密度：1.3

敏感性：对热敏感

折光率：1.63

沸点：657.60° C at 760 mmHg

个人防护装备：Eyeshields， Gloves， type N95 (US)， type P1 (EN143) respirator filter

产品包装