产品名称

英文名称：Neratinib (HKI-272)

同义词

EC 244-343-6、N-(4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)butanamide、CHEBI61397、N-(4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide、NERATIN、来那替尼

产品性质

CAS编号：698387-09-6

分子式：C30H29ClN6O3

分子量：557.04

PubChem编号：9915743

别名：来那替尼

英文别名：EC 244-343-6|N-(4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)butanamide|CHEBI61397|N-(4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide|NERATIN

规格或纯度：≥99%

英文名称：Neratinib (HKI-272)

生化机理：Neratinib is a potent and selective inhibitor of EGFR and Neu(HER2) (IC50 = 92 nM and 59 nM, respectively) by preventing phosphorylation of these proteins by their respective kinases. Neratinib displays activity against a variety of cancer cell lines, including A431, 3T3, and MDA-MB-435. Neratinib is an inhibitor of c-Src and Flk-1.

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：Neratinib (HKI-272)是一种高度选择性的HER2和EGFR抑制剂，IC50分别为59 nM和92 nM；微弱抑制KDR和Src，对Akt，CDK1/2/4， IKK-2， MK-2， PDK1， c-Raf和c-Met没有显著的抑制作用。Phase 3。A potent and selective inhibitor of EGFR and HER2Neratinib (HKI-272) is a highly selective HER2 and EGFR inhibitor with IC50 of 59 nM and 92 nM; weakly inhibits KDR and Src, no significant inhibition to Akt, CDK1/2/4, IKK-2, MK-2, PDK1, c-Raf and c-Met. Phase 3.A potent and selective inhibitor of EGFR and HER2

ALogP：4.9

IUPAC Name：(E)-N-[4-[3-chloro-4-(pyridin-2-ylmethoxy)anilino]-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)but-2-enamide

INCHI：InChI=1S/C30H29ClN6O3/c1-4-39-28-16-25-23(15-26(28)36-29(38)9-7-13-37(2)3)30(20(17-32)18-34-25)35-21-10-11-27(24(31)14-21)40-19-22-8-5-6-12-33-22/h5-12,14-16,18H,4,13,19H2,1-3H3,(H,34,35)(H,36,38)/b9-7+

InChi Key：JWNPDZNEKVCWMY-VQHVLOKHSA-N

Canonical SMILES：CCOC1=C(C=C2C(=C1)N=CC(=C2NC3=CC(=C(C=C3)OCC4=CC=CC=N4)Cl)C#N)NC(=O)C=CCN(C)C

Isomeric SMILES：CCOC1=C(C=C2C(=C1)N=CC(=C2NC3=CC(=C(C=C3)OCC4=CC=CC=N4)Cl)C#N)NC(=O)/C=C/CN(C)C

PubChem CID：9915743

CAS Registry No.：698387-09-6

Wikipedia：Neratinib

DiscoveRx TREEspot：HKI-272|

ChEMBL Ligand：CHEMBL180022

Reactome Reaction：R-HSA-1220611, R-HSA-1225978, R-HSA-9652264, R-HSA-9665412, R-HSA-9665121, R-HSA-9665702, R-HSA-9665286

Reactome Drug：R-ALL-1216527

DrugCentral Ligand：5252

溶解性：Soluble in DMSO (2 mg/ml at 25 °C), water (<1 mg/ml at 25 °C), and ethanol (<1 mg/ml at 25 °C).

产品包装