产品名称

英文名称：Asenapine maleate

同义词

Asenapine maleate、85650-56-2、Saphris、Asenapine (maleate)、Org 5222、Org-5222、Sycrest、Asenapine maleate [USAN]、UNII-CU9463U2E2、Asenapine (as maleate)、CU9463U2E2、EINECS 288-064-8、(Z)-but-2-enedioic acid;(2S,6S)-9-chloro-4-methyl-13-oxa-4-azatetracyclo[12.4.0.、阿塞那平马来酸盐、马来酸阿塞那平

产品性质

CAS编号：85650-56-2

分子式：C17H16ClNO ·C4H4O4

分子量：401.84

EC号：288-064-8

MDL号：MFCD00900588

PubChem编号：6917875

别名：阿塞那平马来酸盐|马来酸阿塞那平

英文别名：Asenapine maleate|85650-56-2|Saphris|Asenapine (maleate)|Org 5222|Org-5222|Sycrest|Asenapine maleate [USAN]|UNII-CU9463U2E2|Asenapine (as maleate)|CU9463U2E2|EINECS 288-064-8|(Z)-but-2-enedioic acid;(2S,6S)-9-chloro-4-methyl-13-oxa-4-azatetracyclo[12.4.0.

规格或纯度：≥98% (HPLC)

英文名称：Asenapine maleate

生化机理：Asenapine maleate is a 5-HT receptor antagonist (5-HT1A,1B, 5-HT2A, 2B, 2C, 5-HT5A, 5-HT6 and 5-HT7), a D2 antagonist, and an antipsychotic.Novel, multiple receptor antagonist. Displays activity at 5-HT, dopamine, adrenoceptors and histamine receptors. (pK i values are 8.60 (5-HT 1A ), 8.40 (5-HT 1B ), 10.15 (5-HT 2A ), 9.75 (5-HT 2B ), 10.46 (5-HT 2C ), 8.84 (5-HT 5A ), 9.60 (5-HT 6 )

应用：Asenapine maleate has been used as a stressor in studying the Fos expression in forebrain structures of rat models. Asenapine maleate is a serotonin 5-HT and dopamine D2 receptor antagonist. Asenapine maleate can be used to treat schizophrenia and bipolar mania.

储存温度：2-8°C储存

运输条件：冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。有毒，请参阅SDS以获取更多信息。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Asenapine maleate是 5-HT(1A, 1B, 2A, 2B, 2C, 5A, 6, 7) 和 D2 的拮抗剂，Ki 值分别为 0.03-4.0 nM, 1.3 nM。同时也是一种抗精神病药物。Asenapine maleate has been used as a stressor in studying the Fos expression in forebrain structures of rat models. Asenapine maleate is a serotonin 5-HT and dopamine D2 receptor antagonist. Asenapine maleate can be used to treat schizophrenia and bipolar mania.Asenapine maleate is a 5-HT (1A, 1B, 2A, 2B, 2C, 5A, 6, 7) and D2 antagonist with Ki values of 0.03-4.0 nM, 1.3nM, respectively, and an antipsychotic.Asenapine maleate is a serotonin 5-HT and dopamine D2 receptor antagonist. Asenapine maleate can be used to treat schizophrenia and bipolar mania.

IUPAC Name：(Z)-but-2-enedioic acid;(2S,6S)-9-chloro-4-methyl-13-oxa-4-azatetracyclo[12.4.0.02,6.07,12]octadeca-1(18),7(12),8,10,14,16-hexaene

INCHI：InChI=1S/C17H16ClNO.C4H4O4/c1-19-9-14-12-4-2-3-5-16(12)20-17-7-6-11(18)8-13(17)15(14)10-19;5-3(6)1-2-4(7)8/h2-8,14-15H,9-10H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t14-,15-;/m1./s1

InChi Key：GMDCDXMAFMEDAG-CHHFXETESA-N

Canonical SMILES：CN1CC2C(C1)C3=C(C=CC(=C3)Cl)OC4=CC=CC=C24.C(=CC(=O)O)C(=O)O

Isomeric SMILES：CN1C[C@H]2[C@H](C1)C3=C(C=CC(=C3)Cl)OC4=CC=CC=C24.C(=C\C(=O)O)\C(=O)O

WGK Germany：3

PubChem CID：6917875

溶解性：DMSO 25 mg/mL (62.21 mM; Need ultrasonic) H2O 6.25 mg/mL (15.55 mM; Need ultrasonic and warming)

敏感性：吸湿、对热敏感

熔点：141 °C

象形图：

信号词：Danger

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH301 Toxic if swallowedH331 Toxic if inhaledH400 Very toxic to aquatic lifeH410 Very toxic to aquatic life with long lasting effectsH372 Causes damage to organs through prolonged or repeated exposureH370 Causes damage to organsH361 Suspected of damaging fertility or the unborn child

预防措施声明：P261,P305+P351+P338,P273,P280,P302+P352,P321,P405,P501,P264,P260,P271,P270,P304+P340,P403+P233,P362+P364,P391,P330,P203,P264+P265,P301+P316,P318,P337+P317,P308+P316,P332+P317,P316,P319

产品包装