产品名称

英文名称：Amonafide

同义词

3-Amino-N-(2-(dimethylamino)ethyl)naphthalimide、AMONAFIDE [WHO-DD]、BCP9000321、BDBM50033894、NCGC00346513-01、Quinamed、Benzisoquinolinedione、5-Amino-2-(2-dimethylamino-ethyl)-benzo[de]isoquinoline-1,3-dione、5-amino-2-(2-dimethylaminoethyl)benzo[de]isoquinoli、AS1413, 氨萘非特

产品性质

CAS编号：69408-81-7

分子式：C16H17N3O2

分子量：283.33

PubChem编号：50515

别名：AS1413, 氨萘非特

英文别名：3-Amino-N-(2-(dimethylamino)ethyl)naphthalimide|AMONAFIDE [WHO-DD]|BCP9000321|BDBM50033894|NCGC00346513-01|Quinamed|Benzisoquinolinedione|5-Amino-2-(2-dimethylamino-ethyl)-benzo[de]isoquinoline-1,3-dione|5-amino-2-(2-dimethylaminoethyl)benzo[de]isoquinoli

规格或纯度：≥98%

英文名称：Amonafide

生化机理：Amonafide is a DNA intercalator and Topo II (topoisomerase II) inhibitor for the treatment of neoplastic diseases. Antitumor agent.Selective topoisomerase II inhibitor. Induces DNA single-strand breaks, double-strand breaks, and DNA-protein cross-links. Shows antiproliferative effects (IC 50 = 3-7 μM). Shows anticancer effects in vivo. Orally active.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Amonafide(AS1413)能通过拓扑异构酶II介导的反应产生蛋白相关的DNA链断裂，但不产生拓扑异构酶I介导的DNA断裂。A DNA intercalator and topoisomerase II inhibitorAmonafide produces protein-associated DNA-strand breaks through a topoisomerase II-mediated reaction, but does not produce topoisomerase I-mediated DNA cleavage.A DNA intercalator and topoisomerase II inhibitor

IUPAC Name：5-amino-2-[2-(dimethylamino)ethyl]benzo[de]isoquinoline-1,3-dione

INCHI：InChI=1S/C16H17N3O2/c1-18(2)6-7-19-15(20)12-5-3-4-10-8-11(17)9-13(14(10)12)16(19)21/h3-5,8-9H,6-7,17H2,1-2H3

InChi Key：UPALIKSFLSVKIS-UHFFFAOYSA-N

Canonical SMILES：CN(C)CCN1C(=O)C2=CC=CC3=CC(=CC(=C32)C1=O)N

Isomeric SMILES：CN(C)CCN1C(=O)C2=CC=CC3=CC(=CC(=C32)C1=O)N

PubChem CID：50515

溶解性：DMSO ≥55mg/mL Water <1.2mg/mL Ethanol ≥3.6mg/mL

熔点：162-164°C

产品包装