产品名称

英文名称：Varespladib

同义词

2-[[3-(2-Amino-2-oxoacetyl)-2-ethyl-1-(phenylmethyl)-1H-indol-4-yl]oxy]acetic acid、DTXSID50169378、2-{[1-benzyl-3-(carbamoylcarbonyl)-2-ethyl-1H-indol-4-yl]oxy}acetic acid、A-001、EN300-19110、NCGC00346491-08、FT-0659937、Varespladib [USAN]、SB16690、AMY19698、FT-、伐瑞拉迪

产品性质

CAS编号：172732-68-2

分子式：C21H20N2O5

分子量：380.39

PubChem编号：155815

别名：伐瑞拉迪

英文别名：2-[[3-(2-Amino-2-oxoacetyl)-2-ethyl-1-(phenylmethyl)-1H-indol-4-yl]oxy]acetic acid|DTXSID50169378|2-{[1-benzyl-3-(carbamoylcarbonyl)-2-ethyl-1H-indol-4-yl]oxy}acetic acid|A-001|EN300-19110|NCGC00346491-08|FT-0659937|Varespladib [USAN]|SB16690|AMY19698|FT-

规格或纯度：≥98%

英文名称：Varespladib

生化机理：Varespladib (LY 315920), a specifically designed indolic secretory phospholipase A2 (sPLA2) inhibitor, has shown promising results in animals and adults. Inhibition seems to be inversely related to the severity of gas exchange impairment. Varespladib acts synergistically with pravastatin to decrease atherosclerosis, possibly throμgh decreased levels of systemic inflammation or decreased lipid levels. Varespladib treatment also resulted in a profound increase in plasma PON activity and significantly larger fibrous caps, sμggesting the formation of more stable plaque architecture.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：5mg、10mg卖完停产，不再备货

产品介绍：Varespladib (LY315920)是一种有效的，选择性的human non-pancreatic secretory phospholipase A2 (hnsPLA)（人类非胰腺分泌型磷脂酶A2）抑制剂，IC50为7 nM。Varespladib (LY315920) is a potent and selective human non-pancreatic secretory phospholipase A2 (hnsPLA) inhibitor with IC50 of 7 nM.

ALogP：2.8

IUPAC Name：2-(1-benzyl-2-ethyl-3-oxamoylindol-4-yl)oxyacetic acid

INCHI：InChI=1S/C21H20N2O5/c1-2-14-19(20(26)21(22)27)18-15(9-6-10-16(18)28-12-17(24)25)23(14)11-13-7-4-3-5-8-13/h3-10H,2,11-12H2,1H3,(H2,22,27)(H,24,25)

InChi Key：BHLXTPHDSZUFHR-UHFFFAOYSA-N

Canonical SMILES：CCC1=C(C2=C(N1CC3=CC=CC=C3)C=CC=C2OCC(=O)O)C(=O)C(=O)N

Isomeric SMILES：CCC1=C(C2=C(N1CC3=CC=CC=C3)C=CC=C2OCC(=O)O)C(=O)C(=O)N

WGK Germany：3

PubChem CID：155815

CAS Registry No.：172732-68-2

ChEMBL Ligand：CHEMBL148674

BindingDB Ligand：50055366

RCSB PDB Ligand：VRD

溶解性：DMSO 76 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

产品包装