产品名称

英文名称：Tandutinib (MLN518)

同义词

Pharmakon1600-01502277、DTXCID5028873、NCGC00241097-07、SMR004702776、UNII-E1IO3ICJ9A、4-[6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinyl]-N-(4-propan-2-yloxyphenyl)-1-piperazinecarboxamide、AMY32698、HMS3654O09、N-(4-isopropoxyphenyl)-4-(6-methoxy-7-(3-(pi、坦度替尼

产品性质

CAS编号：387867-13-2

分子式：C31H42N6O4

分子量：562.72

PubChem编号：3038522

别名：坦度替尼

英文别名：Pharmakon1600-01502277|DTXCID5028873|NCGC00241097-07|SMR004702776|UNII-E1IO3ICJ9A|4-[6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinyl]-N-(4-propan-2-yloxyphenyl)-1-piperazinecarboxamide|AMY32698|HMS3654O09|N-(4-isopropoxyphenyl)-4-(6-methoxy-7-(3-(pi

规格或纯度：≥98%

英文名称：Tandutinib (MLN518)

生化机理：Tandutinib is a piperazinyl quinazoline receptor tyrosine kinase inhibitor with antineoplastic activity. Tandutinib inhibits the autophosphorylation of Flt-3/Flk-2 (FMS-Like Tyrosine kinase-3), c-KIT and PDGF (platelet-derived growth factor) receptor tyrosine kinases, thereby inhibiting cellular proliferation and inducing apoptosis. Tandutinib is an inhibitor of PDGFR-beta.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：卖完停产，不再备货

产品介绍：Tandutinib (MLN518)是一种有效的FLT3拮抗剂，IC50为0.22 μM，同时也抑制PDGFR和c-Kit，对FLT3作用效果比CSF-1R强15到20倍，比FGFR， EGFR和KDR等强100倍以上A piperazinyl quinazoline receptor tyrosine kinase inhibitorTandutinib (MLN518, CT53518) is a potent FLT3 antagonist with IC50 of 0.22 μM, also inhibits PDGFR and c-Kit, 15 to 20-fold higher potency for FLT3 versus CSF-1R and >100-fold selectivity for the same target versus FGFR, EGFR and KDR.A piperazinyl quinazoline receptor tyrosine kinase inhibitor

ALogP：4.6

IUPAC Name：4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-(4-propan-2-yloxyphenyl)piperazine-1-carboxamide

INCHI：InChI=1S/C31H42N6O4/c1-23(2)41-25-10-8-24(9-11-25)34-31(38)37-17-15-36(16-18-37)30-26-20-28(39-3)29(21-27(26)32-22-33-30)40-19-7-14-35-12-5-4-6-13-35/h8-11,20-23H,4-7,12-19H2,1-3H3,(H,34,38)

InChi Key：UXXQOJXBIDBUAC-UHFFFAOYSA-N

Canonical SMILES：CC(C)OC1=CC=C(C=C1)NC(=O)N2CCN(CC2)C3=NC=NC4=CC(=C(C=C43)OC)OCCCN5CCCCC5

Isomeric SMILES：CC(C)OC1=CC=C(C=C1)NC(=O)N2CCN(CC2)C3=NC=NC4=CC(=C(C=C43)OC)OCCCN5CCCCC5

PubChem CID：3038522

CAS Registry No.：387867-13-2

DiscoveRx TREEspot：MLN-518|

Reactome Reaction：R-HSA-9702510, R-HSA-9695831, R-HSA-9702638

Reactome Drug：R-ALL-9695994

溶解性：Soluble in water (very poorly), DMSO (25 mg/ml, with slight warming), ethanol (25 mg/ml, with slight warming), and chloroform.

熔点：172-183°C

产品包装