产品名称

英文名称：Anastrozole

同义词

2-(3-(1-Cyano-1-methylethyl)-5-(1H-1,2,4-triazol-1-ylmethyl)phenyl)-2-methylpropanenitrile、D00960、ANASTROZOLE [USP MONOGRAPH]、DTXSID9022607、Anastrozole (JAN/USP/INN)、ANASTROZOLE (USP-RS)、HMS3369K05、MLS001424217、alpha1,alpha1,alpha3,alpha3-Tetramethyl-5-(1、阿那曲唑

产品性质

CAS编号：120511-73-1

分子式：C17H19N5

分子量：293.37

PubChem编号：2187

别名：阿那曲唑

英文别名：2-(3-(1-Cyano-1-methylethyl)-5-(1H-1,2,4-triazol-1-ylmethyl)phenyl)-2-methylpropanenitrile|D00960|ANASTROZOLE [USP MONOGRAPH]|DTXSID9022607|Anastrozole (JAN/USP/INN)|ANASTROZOLE (USP-RS)|HMS3369K05|MLS001424217|alpha1,alpha1,alpha3,alpha3-Tetramethyl-5-(1

规格或纯度：≥99%

英文名称：Anastrozole

生化机理：对肾上腺皮质激素合成没有明显作用的强效高选择性芳香化酶（CYP19）抑制剂（IC50 = 15 nM）。降低血浆雌激素水平，并在体内表现出抗肿瘤活性。口服有效。

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：Anastrozole is known to inhibit the CYP19 enzyme (aromatase, IC50 = 15 nM) that converts androgens to estrogens. Anastrozole has been seen to reversibly bind to the CYP19 enzyme throμgh competitive inhibition.Anastrozole is known to inhibit the CYP19 enzyme (aromatase, IC50 = 15 nM) that converts androgens to estrogens. Anastrozole has been seen to reversibly bind to the CYP19 enzyme through competitive inhibition.

ALogP：2.1

PubChem SID：488179673

PubChem SID url：https//pubchem.ncbi.nlm.nih.gov/substance/488179673

IUPAC Name：2-[3-(2-cyanopropan-2-yl)-5-(1,2,4-triazol-1-ylmethyl)phenyl]-2-methylpropanenitrile

INCHI：InChI=1S/C17H19N5/c1-16(2,9-18)14-5-13(8-22-12-20-11-21-22)6-15(7-14)17(3,4)10-19/h5-7,11-12H,8H2,1-4H3

InChi Key：YBBLVLTVTVSKRW-UHFFFAOYSA-N

Canonical SMILES：CC(C)(C#N)C1=CC(=CC(=C1)CN2C=NC=N2)C(C)(C)C#N

Isomeric SMILES：CC(C)(C#N)C1=CC(=CC(=C1)CN2C=NC=N2)C(C)(C)C#N

WGK Germany：3

RTECS：CZ1465000

PubChem CID：2187

CAS Registry No.：120511-73-1

DrugBank Ligand：DB01217

Wikipedia：Anastrazole

ChEMBL Ligand：CHEMBL1399

DrugCentral Ligand：210

溶解性：溶于DMSO, 最高浓度 (mg/mL) 29.34, 最高浓度(mM) 100；溶于ethanol, 最高浓度 (mg/mL) 29.34, 最高浓度(mM) 100

象形图：

信号词：Danger

危险声明：H301 Toxic if swallowedH351 Suspected of causing cancerH302 Harmful if swallowedH360 May damage fertility or the unborn child

预防措施声明：P280,P321,P405,P501,P264,P270,P330,P203,P301+P316,P301+P317,P318

产品包装