产品名称

英文名称：NG-Monomethyl-L-arginine Acetate

同义词

L-NMMA acetate、Tilarginine Acetate、53308-83-1、L-NMMA、NG-Monomethyl-L-arginine acetate、NG-Methyl-L-arginine acetate salt、Targinine acetate、Tilarginine acetate [USAN]、L-NMMA (acetate)、ANO-1020、Ng-methylarginine acetate、N-Omega-monomethyl-L-arginine acetate、NG-甲基-L-精氨酸 乙酸盐、Nω-甲基-L-精氨酸 乙酸盐、NG-一甲基-L-精氨酸 乙酸盐、N5-(甲基脒基)-L-鸟氨酸 乙酸盐、L-NMMA 一乙酸酯、N5-[亚氨基(甲基氨基)甲基]-L-鸟氨酸单乙酸盐

产品性质

CAS编号：53308-83-1

分子式：C7H16N4O2·C2H4O2

分子量：248.28

Beilstein号：6674260

MDL号：MFCD00069311

PubChem编号：135242

别名：NG-甲基-L-精氨酸 乙酸盐|Nω-甲基-L-精氨酸 乙酸盐|NG-一甲基-L-精氨酸 乙酸盐|N5-(甲基脒基)-L-鸟氨酸 乙酸盐|L-NMMA 一乙酸酯|N5-[亚氨基(甲基氨基)甲基]-L-鸟氨酸单乙酸盐

英文别名：L-NMMA acetate|Tilarginine Acetate|53308-83-1|L-NMMA|NG-Monomethyl-L-arginine acetate|NG-Methyl-L-arginine acetate salt|Targinine acetate|Tilarginine acetate [USAN]|L-NMMA (acetate)|ANO-1020|Ng-methylarginine acetate|N-Omega-monomethyl-L-arginine acetate|

规格或纯度：≥98%

英文名称：NG-Monomethyl-L-arginine Acetate

生化机理：细胞渗透性竞争性NOS抑制剂。（对于eNOS，iNOS和nNOS，K i值分别为700 nM，3.9 µM和650 nM）。

储存温度：-20°C储存,充氩

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：L-NG-Monomethylarginine, Acetate Salt (L-NMMA), is an analogue of L-arginine that has been shown to inhibit Ca2+-dependent NOS3 (endothelial NOS) from porcine aorta. In an experiment on porcine aortic rings, L-NMMA was shown to cause contraction and inhibition of the endothelium-dependent relaxation induced by acetylcholine. This compound has also been noted to elicit a dose-dependent increase in mean systemic arterial blood pressure accompanied by bradycardia. Experiments on cat vascular endothelia show that L-NMMA can increase leukocyte adherence and emigration and reduce venular shear rate. Low shear rates have been shown to promote platelet-endothelial and leukocyte-endothelial cell adhesion in mesenteric venules. L-NG-Monomethylarginine, Acetate Salt (L-NMMA) is an inhibitor of NOS1 and NOS2.An L-arginine analogue inhibitor of Ca2+-dependent NOS3 (endothelial NOS)L-NG-Monomethylarginine, Acetate Salt (L-NMMA), is an analogue of L-arginine that has been shown to inhibit Ca2+-dependent NOS3 (endothelial NOS) from porcine aorta. In an experiment on porcine aortic rings, L-NMMA was shown to cause contraction and inhibition of the endothelium-dependent relaxation induced by acetylcholine. This compound has also been noted to elicit a dose-dependent increase in mean systemic arterial blood pressure accompanied by bradycardia. Experiments on cat vascular endothelia show that L-NMMA can increase leukocyte adherence and emigration and reduce venular shear rate. Low shear rates have been shown to promote platelet-endothelial and leukocyte-endothelial cell adhesion in mesenteric venules. L-NG-Monomethylarginine, Acetate Salt (L-NMMA) is an inhibitor of NOS1 and NOS2.An L-arginine analogue inhibitor of Ca2+-dependent NOS3 (endothelial NOS)

IUPAC Name：acetic acid;(2S)-2-amino-5-[(N'-methylcarbamimidoyl)amino]pentanoic acid

INCHI：InChI=1S/C7H16N4O2.C2H4O2/c1-10-7(9)11-4-2-3-5(8)6(12)13;1-2(3)4/h5H,2-4,8H2,1H3,(H,12,13)(H3,9,10,11);1H3,(H,3,4)/t5-;/m0./s1

InChi Key：IKPNWIGTWUZCKM-JEDNCBNOSA-N

Canonical SMILES：CC(=O)O.CN=C(N)NCCCC(C(=O)O)N

Isomeric SMILES：CC(=O)O.CN=C(N)NCCC[C@@H](C(=O)O)N

WGK Germany：3

RTECS：RM2982000

PubChem CID：135242

Reaxy-Rn：6674255

溶解性：Soluble in water (25 mg/ml), 100%ethanol (1 mg/ml), DMSO (0.25 mg/ml), methanol, and PBS(pH 7.2).

敏感性：对光和空气敏感，易吸潮

个人防护装备：Eyeshields， Gloves， type N95 (US)， type P1 (EN143) respirator filter

产品包装