产品名称

英文名称：Fumagillin

同义词

fumagillin、23110-15-8、Fugillin、Fumidil、Fumagillinum、Fumagilina、Fumagilline、(-)-Fumagillin、Fumagillina、Amebacilin、Fumagillin DCH、ZGN-201、Amebacillin、Fugilin、CCRIS 9025、DTXSID7040736、UNII-7OW73204U1、CHEBI48635、NSC 9168、NSC-9168、EINECS 245-433-8、2,4,6,8-Dec

产品性质

CAS编号：23110-15-8

分子式：C26H34O7

分子量：458.54

EC号：245-433-8

MDL号：MFCD03990453

PubChem编号：6917655

英文别名：fumagillin|23110-15-8|Fugillin|Fumidil|Fumagillinum|Fumagilina|Fumagilline|(-)-Fumagillin|Fumagillina|Amebacilin|Fumagillin DCH|ZGN-201|Amebacillin|Fugilin|CCRIS 9025|DTXSID7040736|UNII-7OW73204U1|CHEBI48635|NSC 9168|NSC-9168|EINECS 245-433-8|2,4,6,8-Dec

规格或纯度：98%

英文名称：Fumagillin

生化机理：Methionine aminopeptidase-2 (MetAP-2) inhibitor; inhibits endothelial cell proliferation and angiogenesis.Potent, selective and covalent inhibitor of methionine aminopeptidase-2 (MetAP 2 ) (IC 50 = 9.2 nM). Anti-angiogenic. Inhibits endothelial cell proliferation. Inhibits neovascularization and reduces diet-induced obesity in vivo . Orally active.

储存温度：-20°C储存,充氩

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Fumagillin is a complex natural product antibiotic which covalently binds a key histidine residue of methionine aminopeptidase type II (MetAP-2), inhibiting endothelial cell proliferation and angiogenesis.An angiogenesis suppressing antibiotic and MetAP-2 inhibitor.It is an effective treatment for intestinal microsporidiosis caused by Enterocytozoon bieneusi. Used to treat the Nosema disease in honey bees. Applied topically to the conjunctiva in the treatment of microsporidial keratoconjunctivitis. The Research grade Fumagillin is used in the angiogenesis research. In the connection to its anti angiogenetic capabilities, Fumagillin is mentioned as an potential anti-neoplastic antibiotic;Fumagillin is a starting material for several anticancer drμg candidates, such as TNP-470, also shown to be able to protect macrophages from the HIV infectionFumagillin is a complex natural product antibiotic which covalently binds a key histidine residue of methionine aminopeptidase type II (MetAP-2), inhibiting endothelial cell proliferation and angiogenesis.An angiogenesis suppressing antibiotic and MetAP-2 inhibitor.It is an effective treatment for intestinal microsporidiosis caused by Enterocytozoon bieneusi. Used to treat the Nosema disease in honey bees. Applied topically to the conjunctiva in the treatment of microsporidial keratoconjunctivitis. The Research grade Fumagillin is used in the angiogenesis research. In the connection to its anti angiogenetic capabilities, Fumagillin is mentioned as an potential anti-neoplastic antibiotic;Fumagillin is a starting material for several anticancer drug candidates, such as TNP-470, also shown to be able to protect macrophages from the HIV infection

IUPAC Name：(2E,4E,6E,8E)-10-[[(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl]-1-oxaspiro[2.5]octan-6-yl]oxy]-10-oxodeca-2,4,6,8-tetraenoic acid

INCHI：InChI=1S/C26H34O7/c1-18(2)13-14-20-25(3,33-20)24-23(30-4)19(15-16-26(24)17-31-26)32-22(29)12-10-8-6-5-7-9-11-21(27)28/h5-13,19-20,23-24H,14-17H2,1-4H3,(H,27,28)/b7-5+,8-6+,11-9+,12-10+/t19-,20-,23-,24-,25+,26+/m1/s1

InChi Key：NGGMYCMLYOUNGM-CSDLUJIJSA-N

Canonical SMILES：CC(=CCC1C(O1)(C)C2C(C(CCC23CO3)OC(=O)C=CC=CC=CC=CC(=O)O)OC)C

Isomeric SMILES：CC(=CC[C@@H]1[C@@](O1)(C)[C@H]2[C@@H]([C@@H](CC[C@]23CO3)OC(=O)/C=C/C=C/C=C/C=C/C(=O)O)OC)C

WGK Germany：3

RTECS：HE1750000

PubChem CID：6917655

溶解性：Soluble in DMSO (25 mg/ml), ethanol (1 mg/ml), and methanol (slightly soluble). Insoluble in water.

敏感性：对光和空气敏感

沸点：194-195℃

熔点：484.03°C

象形图：

信号词：Warning

危险声明：H302 Harmful if swallowed

预防措施声明：P501,P264,P270,P330,P301+P317

个人防护装备：dust mask type N95 (US), Eyeshields, Gloves

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