产品名称

英文名称：α-Amanitin

同义词

Amanitin、alpha-amanitin、alpha-Amanitine、23109-05-9、.alpha.-Amanitin、alpha -Amanitin、CBiol_001932、CERAPP_20658、SCHEMBL3506327、BCBcMAP01_000054、DTXSID90860291、Bio1_000218、Bio1_000707、Bio1_001196、SMP1_000013、LS-15416、alpha-Amanitin, from Amanita phalloides,、alpha-毒伞肽、alpha-鹅膏覃碱

产品性质

CAS编号：23109-05-9

分子式：C39H54N10O14S

分子量：918.97

Beilstein号：1071138

EC号：245-432-2

MDL号：MFCD00215842

PubChem编号：2100

别名：alpha-毒伞肽|alpha-鹅膏覃碱

英文别名：Amanitin|alpha-amanitin|alpha-Amanitine|23109-05-9|.alpha.-Amanitin|alpha -Amanitin|CBiol_001932|CERAPP_20658|SCHEMBL3506327|BCBcMAP01_000054|DTXSID90860291|Bio1_000218|Bio1_000707|Bio1_001196|SMP1_000013|LS-15416|alpha-Amanitin, from Amanita phalloides,

规格或纯度：≥90%

英文名称：α-Amanitin

生化机理：The major toxic constituent of the mushroom, Amanita phalloides, inhibits eukaryotic RNA polymerase II and III, but does not inhibit RNA polymerase I or bacterial RNA polymerase. Inhibits mammalian protein synthesis.Potent and selective RNA polymerase II inhibitor. Mycotoxin. mRNA synthesis inhibitor. Shows similar effects to γ-amanitin and β-amanitin. Inhibits mammalian protein synthesis in vivo. Orally active.

储存温度：避光,-20°C储存,充氩

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：产品介绍选择性RNA聚合酶II抑制剂；α-Amanitin 是几种致命毒蘑菇的主要毒素，通过抑制RNA 聚合酶 II (RNA-polymerase II) 发挥其毒性作用Product DescribtionA selective RNA polymerase II inhibitor；Alpha-amanitin is the main toxin of several deadly poisonous mushrooms, exerting its toxic effects by inhibiting RNA polymerase IIα-Amanitin is the major toxic bicyclic octapeptide of the Amanita phalloides mushroom that has been used in biochemical research for decades. This toxin is synthesized as a proprotein, on ribosomes, 34 to 35 amino acids in length and then cleaved at specific proline residues by an enzyme belonging to the prolyl oligopeptidase (POP) subfamily. α-Amanitin shows remarkable binding affinity for eukaryotic RNA polymerase II, slightly binds to RNA polymerase III, and shows no activity on RNA polymerase I; it has been used to determine which types of RNA polymerase are present in a given sample. The toxin works by binding to the bridging helix of RNA polymerase II inhibiting the translocation of RNA and DNA needed to empty the site for the next round of synthesis; thereby slowing the rate of transcription by over 1000 fold. α-Amanitin is an inhibitor of Pol III.A specific and potent inhibitor of eukaryotic RNA pol II and a mild inhibitor of RNA pol III.

IUPAC Name：2-[34-butan-2-yl-13-(3,4-dihydroxybutan-2-yl)-8,22-dihydroxy-2,5,11,14,27,30,33,36,39-nonaoxo-27λ4-thia-3,6,12,15,25,29,32,35,38-nonazapentacyclo[14.12.11.06,10.018,26.019,24]nonatriaconta-18(26),19(24),20,22-tetraen-4-yl]acetamide

INCHI：InChI=1S/C39H54N10O14S/c1-4-16(2)31-36(60)42-11-29(55)43-25-15-64(63)38-21(20-6-5-18(51)7-22(20)46-38)9-23(33(57)41-12-30(56)47-31)44-37(61)32(17(3)27(53)14-50)48-35(59)26-8-19(52)13-49(26)39(62)24(10-28(40)54)45-34(25)58/h5-7,16-17,19,23-27,31-32,46,50-53H,4,8-15H2,1-3H3,(H2,40,54)(H,41,57)(H,42,60)(H,43,55)(H,44,61)(H,45,58)(H,47,56)(H,48,59)

InChi Key：CIORWBWIBBPXCG-UHFFFAOYSA-N

Canonical SMILES：CCC(C)C1C(=O)NCC(=O)NC2CS(=O)C3=C(CC(C(=O)NCC(=O)N1)NC(=O)C(NC(=O)C4CC(CN4C(=O)C(NC2=O)CC(=O)N)O)C(C)C(CO)O)C5=C(N3)C=C(C=C5)O

Isomeric SMILES：CCC(C)C1C(=O)NCC(=O)NC2CS(=O)C3=C(CC(C(=O)NCC(=O)N1)NC(=O)C(NC(=O)C4CC(CN4C(=O)C(NC2=O)CC(=O)N)O)C(C)C(CO)O)C5=C(N3)C=C(C=C5)O

WGK Germany：3

RTECS：BD6195000

PubChem CID：2100

溶解性：Soluble in water (1.0 mg/ml), ethanol (5 mM), DMSO, DMF, methanol, and acetonitrile.

敏感性：对光线敏感

熔点：254-255° C

象形图：

信号词：Danger

危险声明：H373 Causes damage to organs through prolonged or repeated exposureH300 Fatal if swallowedH310 Fatal in contact with skinH330 Fatal if inhaled

预防措施声明：P280,P302+P352,P321,P405,P501,P264,P260,P284,P271,P270,P304+P340,P403+P233,P330,P262,P320,P361+P364,P301+P316,P316,P319

个人防护装备：Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

产品包装