产品名称

英文名称：TSU-68 (SU6668, Orantinib)

同义词

Orantinib、TSU-68、252916-29-3、210644-62-5、SU-6668、SU6668、SU 6668、TSU 68、Orantinib [INN]、(Z)-3-(2,4-dimethyl-5-((2-oxoindolin-3-ylidene)methyl)-1H-pyrrol-3-yl)propanoic acid、NSC 702827、Orantinib (SU6668)、2,4-Dimethyl-5-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene

产品性质

CAS编号：252916-29-3

分子式：C18H18N2O3

分子量：310.35

PubChem编号：5329099

英文别名：Orantinib|TSU-68|252916-29-3|210644-62-5|SU-6668|SU6668|SU 6668|TSU 68|Orantinib [INN]|(Z)-3-(2,4-dimethyl-5-((2-oxoindolin-3-ylidene)methyl)-1H-pyrrol-3-yl)propanoic acid|NSC 702827|Orantinib (SU6668)|2,4-Dimethyl-5-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene

规格或纯度：≥98%

英文名称：TSU-68 (SU6668, Orantinib)

生化机理：TSU-68 (SU6668)is a novel multiple receptor tyrosine kinase inhibitor with IC50 of 2.1 μM, 8 nM and 1.2 μM for VEGF-R1, PDGF-Rβ and FGF-R1, respectively.Potent PDGFRβ inhibitor (IC 50 = 60 nM). Also inhibits VEGFR2 and FGFR1 (IC 50 values are 2 and 3 μM respectively). Antiproliferative effects in vitro . Anticancer and proapoptotic activity in vivo . Orally active.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：TSU-68 (SU6668; Orantinib)是多酪氨酸激酶受体抑制剂，对PDGFR自磷酸化抑制性最强，Ki为8 nM，还能相对弱地抑制VEGF-R1和FGF-R1。An antiproliferating agent and ATP-competitive PDGFR, Flk-1/KDR (VEGF), and FGFR inhibitorTSU-68 (SU6668, Orantinib) has greatest potency against PDGFR autophosphorylation with Ki of 8 nM in a cell-free assay, but also strongly inhibits Flk-1 and FGFR1 trans-phosphorylation, little activity against IGF-1R, Met, Src, Lck, Zap70, Abl and CDK2; does not inhibit EGFR. Phase 3.An antiproliferating agent and ATP-competitive PDGFR, Flk-1/KDR (VEGF), and FGFR inhibitor

IUPAC Name：3-[2,4-dimethyl-5-[(Z)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoic acid

INCHI：InChI=1S/C18H18N2O3/c1-10-12(7-8-17(21)22)11(2)19-16(10)9-14-13-5-3-4-6-15(13)20-18(14)23/h3-6,9,19H,7-8H2,1-2H3,(H,20,23)(H,21,22)/b14-9-

InChi Key：NHFDRBXTEDBWCZ-ZROIWOOFSA-N

Canonical SMILES：CC1=C(NC(=C1CCC(=O)O)C)C=C2C3=CC=CC=C3NC2=O

Isomeric SMILES：CC1=C(NC(=C1CCC(=O)O)C)/C=C\2/C3=CC=CC=C3NC2=O

关联CAS：210644-62-5

PubChem CID：5329099

CAS Registry No.：252916-29-3

ChEMBL Ligand：CHEMBL274654

RCSB PDB Ligand：SU6

溶解性：DMSO 62 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

密度：1.33

折光率：1.68

沸点：590.48° C at 760 mmHg

熔点：239.35°C

产品包装