产品名称

英文名称：Balaglitazone

同义词

DRF2593、NN 2344、(+-)-5-(p-((3,4-Dihydro-3-methyl-4-oxo-2-quinazolinyl)methoxy)benzyl)-2,4-thiazolidinedione、UNII-4M1609828O、DRF 2593、DRF-2593、AS-63961、SB16864、4-tert-butyl-phenylsulphonyl chloride、NNC-61-2344、FT-0766930、IETKPTYAGKZLKY-UHFFFAOYSA-N、DB12781、巴格列酮

产品性质

CAS编号：199113-98-9

分子式：C20H17N3O4S

分子量：395.43

PubChem编号：9889200

别名：巴格列酮

英文别名：DRF2593|NN 2344|(+-)-5-(p-((3,4-Dihydro-3-methyl-4-oxo-2-quinazolinyl)methoxy)benzyl)-2,4-thiazolidinedione|UNII-4M1609828O|DRF 2593|DRF-2593|AS-63961|SB16864|4-tert-butyl-phenylsulphonyl chloride|NNC-61-2344|FT-0766930|IETKPTYAGKZLKY-UHFFFAOYSA-N|DB12781

规格或纯度：≥98%

英文名称：Balaglitazone

生化机理：DescriptionIC50 Value N/ABalaglitazone (DRF-2593) is a novel partial agonist of PPAR-gamma (γ), which is developed by Dr. Reddy's laboratories India. Balaglitazone is a second generation peroxisome proliferator-activated receptor (PPAR) gamma agonist with only partial agonistic properties.in vitro The Rs for the separations were 3.5 for balaglitazone enantiomers, 3.5 for pioglitazone enantiomers, and 3.7 for rosiglitazone. The squared correlation coefficients (r2) were found to be 0.999 for all three compounds [1].in vivo Balaglitazone treated groups shown significantly reduce of HbA1c (%), FSG (mmol/L), postprandial glucose as comparison to pioglitazone. Balaglitazone 10 mg and 20 mg show the similar magnitudes of the effects which comparable to the effects seen in the pioglitazone 45 mg group. The incidence of fluid retention and fat accumulation fewer than those observed with pioglitazone 45 mg [2]. Sixty male dio induced obese

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：卖完停产，不再备货

ALogP：2.7

IUPAC Name：5-[[4-[(3-methyl-4-oxoquinazolin-2-yl)methoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione

INCHI：InChI=1S/C20H17N3O4S/c1-23-17(21-15-5-3-2-4-14(15)19(23)25)11-27-13-8-6-12(7-9-13)10-16-18(24)22-20(26)28-16/h2-9,16H,10-11H2,1H3,(H,22,24,26)

InChi Key：IETKPTYAGKZLKY-UHFFFAOYSA-N

Canonical SMILES：CN1C(=NC2=CC=CC=C2C1=O)COC3=CC=C(C=C3)CC4C(=O)NC(=O)S4

Isomeric SMILES：CN1C(=NC2=CC=CC=C2C1=O)COC3=CC=C(C=C3)CC4C(=O)NC(=O)S4

PubChem CID：9889200

溶解性：25°C DMSO

产品包装