产品名称

英文名称：Zibotentan (ZD4054)

同义词

Zibotentan、186497-07-4、ZD4054、Zibotentan (ZD4054)、ZD-4054、2-(4-(1,3,4-oxadiazol-2-yl)phenyl)-N-(3-methoxy-5-methylpyrazin-2-yl)pyridine-3-sulfonamide、N-(3-METHOXY-5-METHYLPYRAZIN-2-YL)-2-[4-(1,3,4-OXADIAZOL-2-YL)PHENYL]PYRIDINE-3-SULFONAMIDE、Zd 4054、Zibot

产品性质

CAS编号：186497-07-4

分子式：C19H16N6O4S

分子量：424.43

PubChem编号：9910224

英文别名：Zibotentan|186497-07-4|ZD4054|Zibotentan (ZD4054)|ZD-4054|2-(4-(1,3,4-oxadiazol-2-yl)phenyl)-N-(3-methoxy-5-methylpyrazin-2-yl)pyridine-3-sulfonamide|N-(3-METHOXY-5-METHYLPYRAZIN-2-YL)-2-[4-(1,3,4-OXADIAZOL-2-YL)PHENYL]PYRIDINE-3-SULFONAMIDE|Zd 4054|Zibot

规格或纯度：≥98%

英文名称：Zibotentan (ZD4054)

生化机理：Zibotentan (ZD4054) is an orally administered, potent and specific ETA-receptor (endothelin A receptor) antagonist (IC50 = 21 nM). Zibotentan is capable of inhibiting or reducing the multitude of effects that are evoked by ET-1 activation of the ETA receptor and which promote tumor survival, growth and progression. Zibotentan (ZD4054) treatment produced significant inhibition of tumor growth in ovarian and breast xenografts.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：5mg、25mg、100mg卖完停产，不再备货

产品介绍：Zibotentan (ZD4054)是口服活性的内皮素A（ETA）受体特异性拮抗剂，IC50为21 nM。A specific ETAR antagonistZibotentan (ZD4054) is a specific Endothelin (ET)A antagonist with IC50 of 21 nM, exhibiting no activity at ETB.A specific ETAR antagonist

ALogP：1.4

IUPAC Name：N-(3-methoxy-5-methylpyrazin-2-yl)-2-[4-(1,3,4-oxadiazol-2-yl)phenyl]pyridine-3-sulfonamide

INCHI：InChI=1S/C19H16N6O4S/c1-12-10-21-17(19(23-12)28-2)25-30(26,27)15-4-3-9-20-16(15)13-5-7-14(8-6-13)18-24-22-11-29-18/h3-11H,1-2H3,(H,21,25)

InChi Key：FJHHZXWJVIEFGJ-UHFFFAOYSA-N

Canonical SMILES：CC1=CN=C(C(=N1)OC)NS(=O)(=O)C2=C(N=CC=C2)C3=CC=C(C=C3)C4=NN=CO4

Isomeric SMILES：CC1=CN=C(C(=N1)OC)NS(=O)(=O)C2=C(N=CC=C2)C3=CC=C(C=C3)C4=NN=CO4

RTECS：UT7937700

PubChem CID：9910224

Wikipedia：Zibotentan

CAS Registry No.：186497-07-4

ChEMBL Ligand：CHEMBL1628688

GPCRdb Ligand：zibotentan

溶解性：DMSO ≥12mg/mL Water <1.2mg/mL Ethanol <1.2mg/mL

象形图：

信号词：Danger

危险声明：H373 Causes damage to organs through prolonged or repeated exposureH411 Toxic to aquatic life with long lasting effectsH360 May damage fertility or the unborn child

预防措施声明：P273,P280,P405,P501,P260,P391,P203,P318,P319

产品包装