产品名称

英文名称：GW501516

同义词

317318-70-0、Endurobol、GW501516、GW 501516、GW-501516、Cardarine、GSK-516、GW1516、GW 1516、UNII-7I2HA1NU22、GW-1516、2-(4-((2-(4-(Trifluoromethyl)phenyl)-4-methylthiazol-5-yl)methylthio)-2-methylphenoxy)acetic acid、2-(2-Methyl-4-(((4-methyl-2-(4-(trifluoromethyl)p、2-[2-甲基-4-[[[4-甲基-2-[4-(三氟甲基)苯基]-5-噻唑基]甲基]硫代]苯氧基]-乙酸

产品性质

CAS编号：317318-70-0

分子式：C21H18F3NO3S2

分子量：453.5

Beilstein号：18515150

MDL号：MFCD09033000

PubChem编号：9803963

别名：2-[2-甲基-4-[[[4-甲基-2-[4-(三氟甲基)苯基]-5-噻唑基]甲基]硫代]苯氧基]-乙酸

英文别名：317318-70-0|Endurobol|GW501516|GW 501516|GW-501516|Cardarine|GSK-516|GW1516|GW 1516|UNII-7I2HA1NU22|GW-1516|2-(4-((2-(4-(Trifluoromethyl)phenyl)-4-methylthiazol-5-yl)methylthio)-2-methylphenoxy)acetic acid|2-(2-Methyl-4-(((4-methyl-2-(4-(trifluoromethyl)p

规格或纯度：≥97%

英文名称：GW501516

生化机理：PPARδ activation by GW501516, retards weight gain through fatty acid catabolism in adipose tissue and skeletal muscles. GW501516 causes an increase in the levels high-density lipoprotein cholesterol and apolipoprotein A (apoA) and reduction in the low density-lipoprotein cholesterol, apoB, and triglyceride. GW501516 is a selective Peroxisome Proliferator-Activated Receptor delta (PPARδ) agonist with high affinity (Ki = 1 nM) and potency (EC50 = 1 nM) for PPARδ and > 1000 fold selectivity over PPARα and PPARγ. GW501516 was shown to activate some of the same pathways activated through exercise, and was investigated as a potential treatment for obesity, diabetes, dyslipidemia and cardiovascular disease. However, GW501516 also showed an increase in cancer in rats.

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：GW 501516 (GW 1516) 是 PPARδ 的激动剂，EC50 值为 1.1 nM。GW501516 has been used to study its effect on mutation-driven colorectal tumorigenesis and tumor invasion using mouse model. GW501516 has been used as a peroxisome proliferator-activated receptor (PPAR) δ agonist to treat the differentiated L6 myotubes to test its effect on free fatty acid (FFA) uptake under mild hypoxia conditions in organoid culture medium to test its effect on self-renewal of PR domain containing 16 (Prdm16)-depleted intestinal stem cells as a component in the defatting medium for primary human hepatocytes (PHH) culture

ALogP：5.9

IUPAC Name：2-[2-methyl-4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methylsulfanyl]phenoxy]acetic acid

INCHI：InChI=1S/C21H18F3NO3S2/c1-12-9-16(7-8-17(12)28-10-19(26)27)29-11-18-13(2)25-20(30-18)14-3-5-15(6-4-14)21(22,23)24/h3-9H,10-11H2,1-2H3,(H,26,27)

InChi Key：YDBLKRPLXZNVNB-UHFFFAOYSA-N

Canonical SMILES：CC1=C(C=CC(=C1)SCC2=C(N=C(S2)C3=CC=C(C=C3)C(F)(F)F)C)OCC(=O)O

Isomeric SMILES：CC1=C(C=CC(=C1)SCC2=C(N=C(S2)C3=CC=C(C=C3)C(F)(F)F)C)OCC(=O)O

RTECS：AI9105500

PubChem CID：9803963

ChEMBL Ligand：CHEMBL38943

BindingDB Ligand：28661

Wikipedia：GW_501516

CAS Registry No.：317318-70-0

NURSA Ligand：10.1621/9IM9FSAA2B

RCSB PDB Ligand：7T1

溶解性：溶于DMSO, 最高浓度 (mg/mL) 45.35, 最高浓度(mM) 100；溶于ethanol, 最高浓度 (mg/mL) 22.68, 最高浓度(mM) 50

产品包装