产品名称

英文名称：BMS-309403

同义词

2-[3-[2-(5-ethyl-3,4-diphenylpyrazol-1-yl)phenyl]phenoxy]acetic acid 、 2-((2'-(5-Ethyl-3,4-diphenyl-1H-pyrazol-1-yl)-[1,1'-biphenyl]-3-yl)oxy)acetic acid、2-(5-乙基-3,4-二苯基-吡唑-1-基)-联苯-3-基氧基]乙酸

产品性质

CAS编号：300657-03-8

分子式：C31H26N2O3

分子量：474.55

PubChem编号：16122583

别名：2-(5-乙基-3,4-二苯基-吡唑-1-基)-联苯-3-基氧基]乙酸

英文别名：2-[3-[2-(5-ethyl-3,4-diphenylpyrazol-1-yl)phenyl]phenoxy]acetic acid | 2-((2'-(5-Ethyl-3,4-diphenyl-1H-pyrazol-1-yl)-[1,1'-biphenyl]-3-yl)oxy)acetic acid

规格或纯度：98%

英文名称：BMS-309403

生化机理：BMS-309403 is a potent, orally active and selective adipocyte fatty acid binding protein (also known as FABP4, aP2) inhibitor with Kis of <2, 250, and 350 nM for FABP4, FABP3, and FABP5, respectively. BMS-309403 interacts with the fatty-acid-binding pocket within the interior of the protein and competitively inhibits the binding of endogenous fatty acids. BMS-309403 improves endothelial function in apolipoprotein E-deficient mice and in cultured human endothelial cells.

储存温度：避光,-20°C储存

运输条件：超低温冰袋运输

产品介绍：产品介绍BMS-309403 是一种有效的选择性脂肪细胞脂肪酸结合蛋白 aFABP，也称作 FABP4 或 aP2，抑制剂，对 FABP4，FABP3 和 FABP5 的 Ki 分别为 <2 nM，250 nM，350 nM。BMS-309403 与蛋白质内部的脂肪酸结合口袋相互作用，竞争性地抑制内源性脂肪酸的结合。BMS-309403 可改善载脂蛋白E缺乏症小鼠和培养的人内皮细胞的内皮功能。Product descriptionBMS-309403 is a potent, orally active and selective adipocyte fatty acid binding protein (also known as FABP4, aP2) inhibitor with Kis of <2, 250, and 350 nM for FABP4, FABP3, and FABP5, respectively. BMS-309403 interacts with the fatty-acid-binding pocket within the interior of the protein and competitively inhibits the binding of endogenous fatty acids. BMS-309403 improves endothelial function in apolipoprotein E-deficient mice and in cultured human endothelial cells；

IUPAC Name：2-[3-[2-(5-ethyl-3,4-diphenylpyrazol-1-yl)phenyl]phenoxy]acetic acid

INCHI：InChI=1S/C31H26N2O3/c1-2-27-30(22-12-5-3-6-13-22)31(23-14-7-4-8-15-23)32-33(27)28-19-10-9-18-26(28)24-16-11-17-25(20-24)36-21-29(34)35/h3-20H,2,21H2,1H3,(H,34,35)

InChi Key：SJRVJRYZAQYCEE-UHFFFAOYSA-N

Canonical SMILES：CCC1=C(C(=NN1C2=CC=CC=C2C3=CC(=CC=C3)OCC(=O)O)C4=CC=CC=C4)C5=CC=CC=C5

Isomeric SMILES：CCC1=C(C(=NN1C2=CC=CC=C2C3=CC(=CC=C3)OCC(=O)O)C4=CC=CC=C4)C5=CC=CC=C5

PubChem CID：16122583

CAS Registry No.：300657-03-8

ChEMBL Ligand：CHEMBL247920

RCSB PDB Ligand：T4B

溶解性：溶于DMSO, 最高浓度 (mg/mL) 47.45, 最高浓度(mM) 100

敏感性：对光线敏感

产品包装