产品名称

英文名称：BI 2536

同义词

BI 2536、755038-02-9、BI-2536、BI2536、(R)-4-((8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl)amino)-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide、UNII-4LJG22T9C6、4LJG22T9C6、4-{[(7r)-8-Cyclopentyl-7-Ethyl-5-Methyl-6-Oxo-5,6,7,8-Tetrahydr

产品性质

CAS编号：755038-02-9

分子式：C28H39N7O3

分子量：521.66

PubChem编号：11364421

英文别名：BI 2536|755038-02-9|BI-2536|BI2536|(R)-4-((8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl)amino)-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide|UNII-4LJG22T9C6|4LJG22T9C6|4-{[(7r)-8-Cyclopentyl-7-Ethyl-5-Methyl-6-Oxo-5,6,7,8-Tetrahydr

规格或纯度：≥98%

英文名称：BI 2536

生化机理：BI 2536 treatment ranging from 10 nM to 100 nM blocks the recruitment of γ-tubulin and phosphorylation of Apc6 at mitotic centrosomes, inhibits of cohesin release from chromosome arms, and induces monopolar spindle formation and other Plk1 dependent processes. BI 2536 treatment leads to the HeLa cells arrested in the G2/M stage. BI 2536 inhibits the growth of a panel of 32 human cancer cell lines with EC50 of 2-25 nM.

储存温度：避光,-20°C储存

运输条件：超低温冰袋运输

产品介绍：BI 2536是一种有效的Plk1抑制剂，IC50为0.83 nM，比作用于Plk2和Plk3选择性分别高4和11倍。A Plk inhibitor with efficacy against 32 cancer cell lines.BI2536 is a potent Plk1 inhibitor with IC50 of 0.83 nM. It shows 4- and 11-fold greater selectivity against Plk2 and Plk3.A Plk inhibitor with efficacy against 32 cancer cell lines.

ALogP：3.7

PubChem SID：488197433

PubChem SID url：https//pubchem.ncbi.nlm.nih.gov/substance/488197433

IUPAC Name：4-[[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide

INCHI：InChI=1S/C28H39N7O3/c1-5-22-27(37)34(3)23-17-29-28(32-25(23)35(22)20-8-6-7-9-20)31-21-11-10-18(16-24(21)38-4)26(36)30-19-12-14-33(2)15-13-19/h10-11,16-17,19-20,22H,5-9,12-15H2,1-4H3,(H,30,36)(H,29,31,32)/t22-/m1/s1

InChi Key：XQVVPGYIWAGRNI-JOCHJYFZSA-N

Canonical SMILES：CCC1C(=O)N(C2=CN=C(N=C2N1C3CCCC3)NC4=C(C=C(C=C4)C(=O)NC5CCN(CC5)C)OC)C

Isomeric SMILES：CC[C@@H]1C(=O)N(C2=CN=C(N=C2N1C3CCCC3)NC4=C(C=C(C=C4)C(=O)NC5CCN(CC5)C)OC)C

PubChem CID：11364421

CAS Registry No.：755038-02-9

DiscoveRx TREEspot：BI-2536|

ChEMBL Ligand：CHEMBL513909

ChEBI：CHEBI49868

RCSB PDB Ligand：R78

溶解性：DMSO 21 mg/mL Water <1 mg/mL Ethanol 100 mg/mL

敏感性：对光线敏感

象形图：

信号词：Warning

危险声明：H302 Harmful if swallowed

预防措施声明：P305+P351+P338,P280

产品包装