产品名称

英文名称：Pralatrexate

同义词

Pralatrexate、146464-95-1、Folotyn、10-Propargyl-10-deazaaminopterin、HSDB 7786、pralatrexato、pralatrexatum、PDX、CHEBI71223、NSC-754230、UNII-A8Q8I19Q20、Pralatrexate(Folotyn)、DTXSID3048578、A8Q8I19Q20、(2S)-2-(4-(1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl)benzamid

产品性质

CAS编号：146464-95-1

分子式：C23H23N7O5

分子量：477.47

PubChem编号：148121

英文别名：Pralatrexate|146464-95-1|Folotyn|10-Propargyl-10-deazaaminopterin|HSDB 7786|pralatrexato|pralatrexatum|PDX|CHEBI71223|NSC-754230|UNII-A8Q8I19Q20|Pralatrexate(Folotyn)|DTXSID3048578|A8Q8I19Q20|(2S)-2-(4-(1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl)benzamid

规格或纯度：≥98%

英文名称：Pralatrexate

生化机理：Pralatrexate acts an inhibitor of DHFR (dihydrofolate reductase).

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：卖完停产，不再备货

产品介绍：An inhibitor of DHFR (dihydrofolate reductase)An inhibitor of DHFR (dihydrofolate reductase)

ALogP：-0.9

IUPAC Name：(2S)-2-[[4-[1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl]benzoyl]amino]pentanedioic acid

INCHI：InChI=1S/C23H23N7O5/c1-2-3-14(10-15-11-26-20-18(27-15)19(24)29-23(25)30-20)12-4-6-13(7-5-12)21(33)28-16(22(34)35)8-9-17(31)32/h1,4-7,11,14,16H,3,8-10H2,(H,28,33)(H,31,32)(H,34,35)(H4,24,25,26,29,30)/t14?,16-/m0/s1

InChi Key：OGSBUKJUDHAQEA-WMCAAGNKSA-N

Canonical SMILES：C#CCC(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O

Isomeric SMILES：C#CCC(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)O)C(=O)O

PubChem CID：148121

DrugBank Ligand：DB06813

CAS Registry No.：146464-95-1

ChEMBL Ligand：CHEMBL1201746

Wikipedia：Pralatrexate

DrugCentral Ligand：4117

溶解性：Soluble in DMSO (28 mg/ml at 25 °C), water (<1 mg/ml at 25 °C), and ethanol (<1 mg/ml at 25 °C). Insoluble in chloroform.

象形图：

信号词：Danger

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH301 Toxic if swallowedH311 Toxic in contact with skinH331 Toxic if inhaledH351 Suspected of causing cancerH372 Causes damage to organs through prolonged or repeated exposureH360 May damage fertility or the unborn childH340 May cause genetic defects

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P260,P281,P271,P270,P304+P340,P403+P233,P362+P364,P330,P361+P364,P203,P264+P265,P301+P316,P318,P337+P317,P332+P317,P316,P319

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