产品名称

英文名称：A-769662

同义词

844499-71-4、A-769662、4-Hydroxy-3-(2'-hydroxy-[1,1'-biphenyl]-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile、A 769662、A769662、6,7-DIHYDRO-4-HYDROXY-3-(2'-HYDROXY[1,1'-BIPHENYL]-4-YL)-6-OXO-THIENO[2,3-B]PYRIDINE-5-CARBONITRILE、4-hydroxy-3-[4-(2

产品性质

CAS编号：844499-71-4

分子式：C20H12N2O3S

分子量：360.39

PubChem编号：54708532

英文别名：844499-71-4|A-769662|4-Hydroxy-3-(2'-hydroxy-[1,1'-biphenyl]-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile|A 769662|A769662|6,7-DIHYDRO-4-HYDROXY-3-(2'-HYDROXY[1,1'-BIPHENYL]-4-YL)-6-OXO-THIENO[2,3-B]PYRIDINE-5-CARBONITRILE|4-hydroxy-3-[4-(2

规格或纯度：≥98%

英文名称：A-769662

生化机理：A-769662 is a potent, reversible AMP-activated protein kinase (AMPK) activator (EC50 = 0.8 μM) that displays selectivity towards β1 subunit-containing heterotrimers. A-769662 inhibits fatty acid synthesis (IC50 = 3.2 μM) and decreases plasma glucose and triglyceride levels in vivo.Potent, reversible activator of AMP-activated protein kinase (AMPK) (EC 50 = 0.8 μM). Directly activates native rat AMPK by mimicking the effects of AMP - it activates AMPK both allosterically and by inhibiting dephosphorylation of AMPK.

应用：An AMPK activator which induces PI3-kinase-dependent glucose uptake

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：A-769662是可逆的AMPK活化剂，EC50为800nM，对GPPase/FBPase几乎无活性。An AMPK activator which induces PI3-kinase-dependent glucose uptakeA-769662 is a potent, reversible AMPK activator with EC50 of 0.8 μM, little effect on GPPase/FBPase activity.An AMPK activator which induces PI3-kinase-dependent glucose uptake

IUPAC Name：4-hydroxy-3-[4-(2-hydroxyphenyl)phenyl]-6-oxo-7H-thieno[2,3-b]pyridine-5-carbonitrile

INCHI：InChI=1S/C20H12N2O3S/c21-9-14-18(24)17-15(10-26-20(17)22-19(14)25)12-7-5-11(6-8-12)13-3-1-2-4-16(13)23/h1-8,10,23H,(H2,22,24,25)

InChi Key：CTESJDQKVOEUOY-UHFFFAOYSA-N

Canonical SMILES：C1=CC=C(C(=C1)C2=CC=C(C=C2)C3=CSC4=C3C(=C(C(=O)N4)C#N)O)O

Isomeric SMILES：C1=CC=C(C(=C1)C2=CC=C(C=C2)C3=CSC4=C3C(=C(C(=O)N4)C#N)O)O

PubChem CID：54708532

CAS Registry No.：844499-71-4

ChEMBL Ligand：CHEMBL512504

RCSB PDB Ligand：C1V

BindingDB Ligand：50242401

溶解性：DMSO ≥70mg/mL Water <1.2mg/mL Ethanol <1.2mg/mL

密度：1.56

折光率：1.78

沸点：630.08° C at 760 mmHg

熔点：268.39°C

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH302 Harmful if swallowedH312 Harmful in contact with skinH332 Harmful if inhaled

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P501,P264,P271,P270,P304+P340,P362+P364,P330,P264+P265,P301+P317,P317,P337+P317,P332+P317

产品包装