产品名称

英文名称：Cinoxacin

同义词

(1,3)DIOXOLO(4,5-G)CINNOLINE-3-CARBOXYLIC ACID, 1-ETHYL-1,4-DIHYDRO-4-OXO、(1,3)Dioxolo(4,5-g)cinnoline-3-carboxylic acid, 1-ethyl-1,4-dihydro-4-oxo-、5-Ethyl-8-oxo-5,8-dihydro-1,3-dioxa-5,6-diaza-cyclopenta[b]naphthalene-7-carboxylic acid、BPBio1_000946、Cin、西诺沙星

产品性质

CAS编号：28657-80-9

分子式：C12H10N2O5

分子量：262.22

EC号：249-133-8

MDL号：MFCD00056776

PubChem编号：2762

别名：西诺沙星

英文别名：(1,3)DIOXOLO(4,5-G)CINNOLINE-3-CARBOXYLIC ACID, 1-ETHYL-1,4-DIHYDRO-4-OXO|(1,3)Dioxolo(4,5-g)cinnoline-3-carboxylic acid, 1-ethyl-1,4-dihydro-4-oxo-|5-Ethyl-8-oxo-5,8-dihydro-1,3-dioxa-5,6-diaza-cyclopenta[b]naphthalene-7-carboxylic acid|BPBio1_000946|Cin

规格或纯度：≥99%

英文名称：Cinoxacin

生化机理：Cinoxacin interferes with DNA replication by inhibiting DNA gyrase and topoisomerase IV (topo IV) throμgh tight DNA binding. Cinoxacin allows for proper replicated DNA separation. Therefore, the inhibition of Cinoxacin inhibits DNA replication and cell division.

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：Cinoxacin is an antibacterial quinolone analog of oxolinic acid. The compound has been documented to block DNA synthesis throμgh inhibition of Topo II (DNA gyrase) as well as topoisomerase IV. Cinoxacin has been observed to block both topoisomerse IV in both prokaryotic and eukaryotic cell lines. Due to the inhibiting activity of Cinoxacin the compound has displayed toxicity against eukaryotic cells. In vitro studies have shown the renal damage caused by Cinoxacin to be attributed to deposition of Cinoxacin crystals in the urinary tract.Cinoxacin is a synthetic antimicrobial commonly used in urinary tract infections that are caused by Escherichia coli, Proteus mirabilis, Proteus vulgaris, Klebsiella species, and Enterobacter species.. It is a quinolone gyrase inhibitor. It is used to study the rat renal organic anion transporter 1 (OAT1)1. It is used to study fluoroquinolone-resistant Streptococcus pyogenes2.product descriptionCinoxacin is an antibacterial quinolone analog of oxolinic acid. The compound has been documented to block DNA synthesis throμgh inhibition of Topo II (DNA gyrase) as well as topoisomerase IV. Cinoxacin has been observed to block both topoisomerse IV in both prokaryotic and eukaryotic cell lines. Due to the inhibiting activity of Cinoxacin the compound has displayed toxicity against eukaryotic cells. In vitro studies have shown the renal damage caused by Cinoxacin to be attributed to deposition of Cinoxacin crystals in the urinary tract.Cinoxacin is a synthetic antimicrobial commonly used in urinary tract infections that are caused by Escherichia coli, Proteus mirabilis, Proteus vulgaris, Klebsiella species, and Enterobacter species.. It is a quinolone gyrase inhibitor. It is used to study the rat renal organic anion transporter 1 (OAT1). It is used to study fluoroquinolone-resistant Streptococcus pyogenes.

ALogP：2.1

IUPAC Name：1-ethyl-4-oxo-[1,3]dioxolo[4,5-g]cinnoline-3-carboxylic acid

INCHI：InChI=1S/C12H10N2O5/c1-2-14-7-4-9-8(18-5-19-9)3-6(7)11(15)10(13-14)12(16)17/h3-4H,2,5H2,1H3,(H,16,17)

InChi Key：VDUWPHTZYNWKRN-UHFFFAOYSA-N

Canonical SMILES：CCN1C2=CC3=C(C=C2C(=O)C(=N1)C(=O)O)OCO3

Isomeric SMILES：CCN1C2=CC3=C(C=C2C(=O)C(=N1)C(=O)O)OCO3

PubChem CID：2762

Antibiotic DB：2028

ChEMBL Ligand：CHEMBL1208

ChEBI：CHEBI3716

DrugBank Ligand：DB00827

DrugCentral Ligand：657

CAS Registry No.：28657-80-9

溶解性：Soluble in alka line solutions (pH 10 or more), and most polar organic solvents.. Insoluble in water.

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritation

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P304+P340,P403+P233,P362+P364,P264+P265,P337+P317,P332+P317,P319

产品包装