产品名称

英文名称：5-Fluoro-2′-deoxyuridine

同义词

floxuridine、50-91-9、5-Fluorodeoxyuridine、2'-Deoxy-5-fluorouridine、Fluorodeoxyuridine、FUDR、Floxuridin、FdUrd、5-Fluoro-2'-deoxyuridine、Deoxyfluorouridine、Fluoruridine deoxyribose、5FdU、Floxiridina、Floxuridinum、5-Fluoro-2-desoxyuridine、5-Fluorouracil 2'-deoxyr、2'-脱氧-5-氟尿苷、1-(2-脱氧-β-D-呋喃核糖基)-氟尿嘧啶、氟尿苷、2'-脱氧-5-氟脲苷、氟脲苷

产品性质

CAS编号：50-91-9

分子式：C9H11FN2O5

分子量：246.19

MDL号：MFCD00006530

PubChem编号：5790

别名：2'-脱氧-5-氟尿苷|1-(2-脱氧-β-D-呋喃核糖基)-氟尿嘧啶|氟尿苷|2'-脱氧-5-氟脲苷|氟脲苷

英文别名：floxuridine|50-91-9|5-Fluorodeoxyuridine|2'-Deoxy-5-fluorouridine|Fluorodeoxyuridine|FUDR|Floxuridin|FdUrd|5-Fluoro-2'-deoxyuridine|Deoxyfluorouridine|Fluoruridine deoxyribose|5FdU|Floxiridina|Floxuridinum|5-Fluoro-2-desoxyuridine|5-Fluorouracil 2'-deoxyr

规格或纯度：99%

英文名称：5-Fluoro-2′-deoxyuridine

生化机理：Antineoplastic drμg that acts as a potent inhibitor of thymidylate synthetase Resistance to FUdR can develop in cancer cell cultures, among other means, by low-level Mycoplasma infection.Prodrug. Antimetabolite antineoplastic agent. Shows more potent antineoplastic effects than analog, 5-Fluorouracil ( Asc 2387 ). Shows antitumor effects in vivo.

储存温度：2-8°C储存

运输条件：冰袋运输

备注：100mg、500mg卖完停产，不再备货；如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：5-Fluoro-2′-deoxyuridine, also called floxuridine elicits DNA-directed cytotoxicity in cancer cells. Floxuridine is effective for treating liver cancer and eliminating virulence of Staphylococcus aureus. Dipeptide prodrμgs combination of floxuridine with gemcitabine are more cell permeable and display enhanced anti-proliferative activity. Floxuridine is effective on solid tumours and advanced stage cancers.5-Fluoro-2′-deoxyuridine has been used as a mitotic inhibitor in schwann cell proliferation, glia proliferation and nonneuronal cells in dorsal root ganglion cultures.5-Fluoro-2′-deoxyuridine, also called floxuridine elicits DNA-directed cytotoxicity in cancer cells. Floxuridine is effective for treating liver cancer and eliminating virulence of Staphylococcus aureus. Dipeptide prodrugs combination of floxuridine with gemcitabine are more cell permeable and display enhanced anti-proliferative activity. Floxuridine is effective on solid tumours and advanced stage cancers.5-Fluoro-2′-deoxyuridine has been used as a mitotic inhibitor in schwann cell proliferation, glia proliferation and nonneuronal cells in dorsal root ganglion cultures.

ALogP：-1.2

IUPAC Name：5-fluoro-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione

INCHI：InChI=1S/C9H11FN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1

InChi Key：ODKNJVUHOIMIIZ-RRKCRQDMSA-N

Canonical SMILES：C1C(C(OC1N2C=C(C(=O)NC2=O)F)CO)O

Isomeric SMILES：C1[C@@H]([C@H](O[C@H]1N2C=C(C(=O)NC2=O)F)CO)O

RTECS：YU7525000

PubChem CID：5790

UN Number：1760

Packing Group：I

Reaxy-Rn：90221

DrugBank Ligand：DB00322

CAS Registry No.：50-91-9

Wikipedia：Floxuridine

ChEMBL Ligand：CHEMBL917

DrugCentral Ligand：1184

溶解性：Soluble in water, alcohol, isopropyl alcohol, methanol, aqueous buffers, acetone, dimethyl sulfoxide, and ethanol. Insoluble in ether, benzene and chloroform.

密度：1.64

敏感性：对热敏感

比旋光度：38 ° (C=1, H2O)

熔点：148°C

象形图：

信号词：Danger

危险声明：H301 Toxic if swallowedH341 Suspected of causing genetic defects

预防措施声明：P321,P405,P501,P264,P281,P270,P330,P203,P301+P316,P318

Class：8

Merck Index：4112

产品包装