产品名称

英文名称：Pomalidomide

同义词

Pomalidomide、19171-19-8、Actimid、4-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione、Pomalyst、CC-4047、Imnovid、4-Aminothalidomide、4-Amino-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione、IMiD 3、1H-Isoindole-1,3(2H)-dione, 4-amino-2-(2,6-dioxo-3-piperidin、泊马度胺、TNF-alpha抑制剂

产品性质

CAS编号：19171-19-8

分子式：C13H11N3O4

分子量：273.24

MDL号：MFCD12756407

PubChem编号：134780

别名：泊马度胺|TNF-alpha抑制剂

英文别名：Pomalidomide|19171-19-8|Actimid|4-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione|Pomalyst|CC-4047|Imnovid|4-Aminothalidomide|4-Amino-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione|IMiD 3|1H-Isoindole-1,3(2H)-dione, 4-amino-2-(2,6-dioxo-3-piperidin

规格或纯度：≥99%

英文名称：Pomalidomide

生化机理：Pomalidomide is tumor necrosis factor-α inhibitor and a new immunomodulator with an IC50 of 1 μM.Pomalidomide is thalidomide derivative that displays inhibition of LPS-induced TNFα release. Shows immunomodulator and anticancer effects.Inhibits LPS-induced TNF-α. Antiangiogenic agent. Thalidomide derivative. Shows antiproliferative and immunomodulatory effects in vivo. Orally active.

储存温度：2-8°C储存

运输条件：冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Pomalidomide抑制LPS诱导的TNF-alpha释放， IC50为13 nM。Pomalidomide is a second generation immunomodulator, TNF-α inhibitor, and thalidomide analog. An inhibitor of LPS-induced TNFαrelease.Pomalidomide inhibits LPS-induced TNF-α release with IC50 of 13 nM.Pomalidomide is a second generation immunomodulator, TNF-α inhibitor, and thalidomide analog. An inhibitor of LPS-induced TNFαrelease.

ALogP：0.2

IUPAC Name：4-amino-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione

INCHI：InChI=1S/C13H11N3O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11(8)18/h1-3,8H,4-5,14H2,(H,15,17,18)

InChi Key：UVSMNLNDYGZFPF-UHFFFAOYSA-N

Canonical SMILES：C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)N

Isomeric SMILES：C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)N

WGK Germany：2

PubChem CID：134780

ChEMBL Ligand：CHEMBL43452

DrugBank Ligand：DB08910

Wikipedia：Pomalidomide

CAS Registry No.：19171-19-8

Reactome Reaction：R-HSA-9681169

Reactome Drug：R-ALL-9681202

DrugCentral Ligand：4746

溶解性：Soluble in DMSO (55 mg/ml at 25 °C), water (<1 mg/ml at 25 °C), ethanol (<1 mg/ml at 25 °C), 1% DMSO/30% polyethylene glycol/1% Tween 80 (15 mg/ml at 25 °C), and THF (sparingly).

敏感性：对热敏感

闪点(℉)：66.2°F

闪点(℃)：66.2°F

熔点：315.5-317.5°C

象形图：

信号词：Danger

危险声明：H373 Causes damage to organs through prolonged or repeated exposureH360 May damage fertility or the unborn childH360Df May damage the unborn child; Suspected of damaging fertilityH361 Suspected of damaging fertility or the unborn child

预防措施声明：P280,P405,P501,P260,P203,P318,P319

Merck Index：135

产品包装