产品名称

英文名称：Retinoic acid

同义词

(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid、TRETINOIN COMPONENT OF ZIANA、Tretinoina (INN-Spanish)、Avita (0.025% gel)、Retinoate、Tretinoina [INN-Spanish]、b-Retinoic acid、Tretinoin [USANUSPINNBAN]、Tretinoin、维A酸

产品性质

CAS编号：302-79-4

分子式：C20H28O2

分子量：300.44

Beilstein号：2057223

EC号：206-129-0

MDL号：MFCD00001551

PubChem编号：444795

别名：维A酸

英文别名：(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid|TRETINOIN COMPONENT OF ZIANA|Tretinoina (INN-Spanish)|Avita (0.025% gel)|Retinoate|Tretinoina [INN-Spanish]|b-Retinoic acid|Tretinoin [USANUSPINNBAN]|Tretinoin

规格或纯度：分析标准品

英文名称：Retinoic acid

生化机理：Description IC50 Value N/A All-trans retinoic acid (ATRA) has been widely investigated for treatments of many cancers including prostate cancer. in vitro ATRA was able to induce the growth arrest and to increase HOXB13 expression in AR?prostate cancer cells. Both EZH2 and DNMT3b participated in the repression of HOXB13 expression throμgh an epigenetic mechanism involving DNA and histone methylation modifications[1]. ATRA could upregulate HOXB13 throμgh decreasing EZH2 and DNMT3b expressions and reducing their interactions with the HOXB13 promoter[1]. in vivo Earlier studies revealed that treatment of leukemic cells with ATRA resulted in the apoptosis, presumably secondary to the differentiation process. Since ATRA can rectify aberrant cell growth and induce apoptosis, it has been widely investigated in preclinical and clinical trials for the treatment of many cancer types, including early gastric cancer and prostate cancer . In AR? and drμg resistant DU145 prostate cancer cells, ATRA was demonstrated to increase the sensitivity of cells to anticancer agent docetaxel[1]. All-trans retinoic acid (ATRA) induces clinical remission in APL patients by enhancing the rapid differentiation of APL cells and the clearance of PML-RARα, APL's hallmark oncoprotein[2]. Clinical trial N/A

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：不溶于水，溶于乙醚、DMSO (25 mg/ml)；微溶于乙醇和氯仿。

ALogP：6.3

IUPAC Name：(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoic acid

INCHI：InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+

InChi Key：SHGAZHPCJJPHSC-YCNIQYBTSA-N

Canonical SMILES：CC1=C(C(CCC1)(C)C)C=CC(=CC=CC(=CC(=O)O)C)C

Isomeric SMILES：CC1=C(C(CCC1)(C)C)/C=C/C(=C/C=C/C(=C/C(=O)O)/C)/C

WGK Germany：2

RTECS：VH6475000

PubChem CID：444795

Reaxy-Rn：2057223

ChEMBL Ligand：CHEMBL38

BindingDB Ligand：31883

DrugBank Ligand：DB00755

ChEBI：CHEBI15367

Wikipedia：Tretinoin

CAS Registry No.：302-79-4

NURSA Ligand：10.1621/3ZT36894UZ

RCSB PDB Ligand：3KV, REA

PEP：tretinoin

DrugCentral Ligand：2722

密度：1.011

熔点：180-181°C

象形图：

信号词：Danger

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH360 May damage fertility or the unborn child

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P304+P340,P403+P233,P362+P364,P203,P264+P265,P318,P337+P317,P332+P317,P319

Merck Index：8165

个人防护装备：dust mask type N95 (US),Eyeshields,Gloves

产品包装