产品名称

英文名称：Nocodazole

同义词

nocodazole、31430-18-9、Oncodazole、R 17934、Nocodazolum、Nocodazol、NSC 238159、NSC-238159、R 17,934、C14H11N3O3S、Methyl N-[6-(thiophene-2-carbonyl)-1H-benzimidazol-2-yl]carbamate、Methyl 5-(2-thenoyl)-2-benzimidazolecarbamate、methyl (5-(thiophene-2-carbonyl)-1H-b、[5-(2-噻吩羰基)-1H-苯并咪唑-2-基]氨基甲酸甲酯、甲基N(5-噻吩甲酰-2-苯并咪唑基)氨基甲酸、甲基-(5-噻吩甲酰-2-苯并咪唑基)氨基甲酸

产品性质

CAS编号：31430-18-9

分子式：C14H11N3O3S

分子量：301.32

Beilstein号：1085978

EC号：250-626-5

MDL号：MFCD00005588

PubChem编号：4122

别名：[5-(2-噻吩羰基)-1H-苯并咪唑-2-基]氨基甲酸甲酯|甲基N(5-噻吩甲酰-2-苯并咪唑基)氨基甲酸|甲基-(5-噻吩甲酰-2-苯并咪唑基)氨基甲酸

英文别名：nocodazole|31430-18-9|Oncodazole|R 17934|Nocodazolum|Nocodazol|NSC 238159|NSC-238159|R 17,934|C14H11N3O3S|Methyl N-[6-(thiophene-2-carbonyl)-1H-benzimidazol-2-yl]carbamate|Methyl 5-(2-thenoyl)-2-benzimidazolecarbamate|methyl (5-(thiophene-2-carbonyl)-1H-b

规格或纯度：≥98%

英文名称：Nocodazole

生化机理：Nocodazole是一种微管聚合的快速可逆抑制剂，也抑制Abl， Abl(E255K)和Abl(T315I)，IC50分别为0.21 μM， 0.53 μM和0.64 μM。微管抑制剂。在体内快速解聚微管，在体外抑制微管蛋白聚合。抑制有丝分裂。还降低了干细胞多能性因子Oct 4和Nanog。

应用：A potent Tubulin production inhibitor and anti-neoplastic agent

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Nocodazole is a reversible anti-neoplastic agent which exerts its effect in cells by interfering with the polymerization of microtubules (tubulin). Several drμgs including vincristine and colcemid are similar to nocodazole in that they interfere with microtubule polymerization. Nocodazole is frequently employed in cell biology laboratories to synchronize the cell division cycle; cells treated with nocodazole arrest with a G2- or M-phase DNA content when analyzed by flow cytometry. Nocodazole has also been used to induce the formation of Golgi ministacks in eukaryotic cells due to lack of proper Tubulin function.A potent Tubulin production inhibitor and anti-neoplastic agentNocodazole is a reversible anti-neoplastic agent which exerts its effect in cells by interfering with the polymerization of microtubules (tubulin). Several drugs including vincristine and colcemid are similar to nocodazole in that they interfere with microtubule polymerization. Nocodazole is frequently employed in cell biology laboratories to synchronize the cell division cycle; cells treated with nocodazole arrest with a G2- or M-phase DNA content when analyzed by flow cytometry. Nocodazole has also been used to induce the formation of Golgi ministacks in eukaryotic cells due to lack of proper Tubulin function.A potent Tubulin production inhibitor and anti-neoplastic agent

IUPAC Name：methyl N-[6-(thiophene-2-carbonyl)-1H-benzimidazol-2-yl]carbamate

INCHI：InChI=1S/C14H11N3O3S/c1-20-14(19)17-13-15-9-5-4-8(7-10(9)16-13)12(18)11-3-2-6-21-11/h2-7H,1H3,(H2,15,16,17,19)

InChi Key：KYRVNWMVYQXFEU-UHFFFAOYSA-N

Canonical SMILES：COC(=O)NC1=NC2=C(N1)C=C(C=C2)C(=O)C3=CC=CS3

Isomeric SMILES：COC(=O)NC1=NC2=C(N1)C=C(C=C2)C(=O)C3=CC=CS3

WGK Germany：3

RTECS：DD6521000

PubChem CID：4122

UN Number：2811

Packing Group：I

溶解性：Soluble in DMSO (10 mg/ml);Soluble in Ethanol (1 mg/ml)

敏感性：对热敏感

熔点：260 °C

象形图：

信号词：Warning

危险声明：H341 Suspected of causing genetic defectsH361 Suspected of damaging fertility or the unborn child

预防措施声明：P280,P405,P501,P281,P203,P318

Class：6.1

个人防护装备：Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter

产品包装